The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Neuroprotective Effect of Gastrodiae Rhizoma on Global Ischemia Induced by 4-Vessel Occlusion in Rats

천마(天麻)의 4-Vessel Occlusion으로 유발한 흰쥐 전뇌허혈에 대한 신경보호 효과

Kim Ho-Cheol;Ahn Duk-Kyun
김호철;안덕균

  • Published : 19990000

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Abstract

Gastrodiae Rhizoma(GR), the rhizoma of Gastrodia elata $B_L.$, has been used for the effect of calming the liver(平肝) in Traditional Korean Medicine. We hypothesized this effect of calming the liver has relations with the effects of curing stroke. So, this study was planned to check the neuroprotective effect of GR on the global ischemia induced by 4-vessel occlusion in Wister rats. GR extract was lyophilized with ethanol after reflux extraction with water. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of $CA_1$ pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The result showed significant protective effects of samples compared with control group which was administrated with normal saline in the intraperitoneal injection of 1200mg/kg and 600mg/kg of Gastrodiae Rhizoma extracts at 0, 2 and 6 hours after inducing cerebral ischemia. We also observed the same results when it was injected at 30 minutes before inducing ischemia. The extract of GR did not lower body temperature at these dosages. Further study will be needed to separate the active ingredients of GR and study molecular biological mechanism for developing neuroprotective drug.

Keywords

References

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