대한본초학회지 (The Korea Journal of Herbology)

  • 제14권1호
  • /
  • Pages.103-103
  • /
  • 1999
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

파킨슨병에서의 도파민성 신경세포손상에 대한 천마(天麻)의 방어효과에 관한 연구

Neuroprotective Effect of Gastrodiae Rhizoma on Dopaminergic Neuronal Cell Death in Parkinson's disease

김호철;이복남;김용식;이상인
Kim Ho-Cheol;Lee Bok-Nam;Kim Yong-Sik;Lee Sang-In

  • 발행 : 19990000

⟨ 이전 논문 다음 논문 ⟩

초록

Parkinson's disease is characterized by chronic progress of mesencephalic dopaminergic neuronal death. The activity of mitochondrial complex I of the dopaminergic neuron is reduced in Parkinson's disease, and the reduction of mitochondrial complex I activity seems to play an improtant role in the degenerative process of the dopaminergic neuron. Methyl-4-phenylpyridium ion ($MPP^+$) is taken up selectively into the dopaminergic neuron and causes reduction of mitochondrial complex I acivity and dopaminergic neuronal death. Gastrodiae Rhizoma, the rhizoma of Gastrodia elara $B_L.$, has been used for the effect of calming the liver in Tradicional Korean Medicine. This drug has especially used for the sign of tremer in Traditional Korean Medicine, which is one of the main simptom in Parkinson's disease. Gastrodiae Rhizoma has reportedly antioxidant, glutamate antagonistic and GABA agonistic effects. We hypothesized that Gastrodiae Rhizoma has the neuroprotective effect on the dopaminergic cell death induced by $MPP^+$ treatment as a model of Parkinsonism. In our experiments, $MPP^+$ caused cytotoxicity mainly in the dopaminergic neuron of S.D. rat fetal mesencephalon in a dose-dependent manner. More than $0.5% MPP^+$ showed reduction of the number of dopaminergic neuron. We investigated the neuroprotective effect of Gastrodiae Rhizoma after treatment with $0.5% MPP^+$ and checked the dopamine and DOPAC level, dopamine uptake and TH cell number. At the dose of G. elata 20 mg/ml. there is no significant protective effects in the sample group induced by $0.5% MPP^+$ treatment. We conclude that G. elata has no neuroprotective effect on the cytotoxicity induced by $MPP^+$ in dopaminergic cell culture.

키워드

참고문헌

  1. J Neural Transm v.19 Neuromelanin and Parkinson's disease Marsden, CD
  2. 實用中西醫結合診斷治療學 陳貴延;楊思澍
  3. 本草學 李尙仁(외)
  4. Butterworth Scientific Fluctuations of disability in Parkinson's disease-clinical aspects, Movement disorders Marsden, CD;Parker, JD;Quinn, N;Marsden, CD;Fahns
  5. NEJM v.327 Survival of implanted fetal dopamine cells and neurologic miprovement 12 to 46 months after transplantation for Parkinson's disease Freed, CR;Breeze, RE;Rosenberg, NL(et al.)
  6. J Neural Transm v.19 Neuromelanin and Parkinson's disease Marsden, CD
  7. Acta Neuro Scand Suppl v.95 Problems associated with long-tern levodopa treatment of Parkinson's disease Rinne, UK
  8. Hua Hsi I Ko Ta Hwueh Pao v.23 Effects of tian-ma injection on myocardial ischemia and lipid peroxidation in rabbits Luo, H;Wang, L;Chen, H;Xue, Z
  9. Neuropharmacology v.31 Antioxidant and free radical scanvenging activities of Gastrodia elata Bl. amd Uncaria rhynchophylla (Miq.) Jacks Liu, J;Mori, A
  10. Neuropharmacology v.32 Antioxidant and pro-oxidant activities of p-hydroxybenzyl alcohol and vanillin: effects in free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acids and DNA Liu, J;Mori, A
  11. Pharmacol Biochem Behav v.60 Ameliorating effect of p-hydroxybenzyl clcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-HT1A and 5-HT2 receptors Hsieh, MT;Wu, CR;Hsieh, CC
  12. Chung Kuo I Hsueh Ko Yuan Hsueh Pao v.11 Comparison strudies on pharmacological properties of injectio Gastrodia elata, gastrodin-free fraction and gastrodin Huang, JH
  13. Chin J Physiol v.39 P-hydroxybenzyl alcohol attenuates learning deficits in the inhibitory avoidance task: involvement of serotonergic and dopaminergic systems Wu, CR;Hsieh, MT;Liao, J
  14. Plata Med v.62 Effect of Gastrodia elata and its active constituents on scopolamine-induced amnesia in rats Wu, CR;Hsieh, MT;Huang, SC;Peng, WH;Chang, YS;Chen, CF
  15. J Mthnopharmacol v.56 Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats Hsieh, MT;Wu, CR;Chen, CF
  16. Yao Hsueh Hsueh Pao v.23 The effect of vanilin on the fully amygdala-kindled seizures in the rat Wu, HQ;Xie, L;Jin, XN;Ge, Q;Jin, H;Liu, GQ
  17. Hua Hsi I Ko Ta Hsueh Hsueh Pao v.22 Study of the mechanism of gastrodin and derivatives of gastrodigenin Guo, Z;Tan, T;Ahong, Y;Wu,C
  18. Phytochemistry v.38 Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia Andersson, M;Bergendorff, O;Nielsen, M;Sterner, O;Witt, R;Ai, J(et al.)
  19. J Neurochem v.51 Studies on the metabolism and toxicity of MPTP in cultures of embryonic rat mesencephalon Nytilineus, CC;Friedman, L
  20. Ann Neurol v.26 Abnormalities of the electron transport chain in idiopathic Parkinson's disease Parker, WD Jr;Boyson, SJ;Parks, JK
  21. J Neurochem v.54 Mitochondrial complex I deficiency in Parkinson's disease Schapira, AH;Cooper, JM;Dexter, D;Clark, JB;Jenner, P; Marsden, CD
  22. Ann Neurol v.32 Mitochondrial function in Parkinson's disease Schapira, AH;Mann, VM;Cooper, JM;Krige, D;Jenner, PJ
  23. Life Sci v.36 Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-pheynl-1, 2, 3, 6-tetrahydropyridine Nicklas, WJ;Vyas, I;Heikkila, RE
  24. Biochem Biophys Res Commun v.169 Evidencd that the blockade of mitochondrial respiration by the neurotoxin 1-methyl-4-phenyl-pyridium (MPP+) invilves binding at the same site as the respiratory inhibitor, rotenone Krueger, MJ;Singer, TP;Casida, JE;Ramsay, RR
  25. Psychiatry v.1 Chronic parkinsonism secondary to intravenous injection of meperidine analogues Davis, GC;Williams, AC;Markey, SP;Ebert, MH;Caine, ED;Reichert, CM(et al.)
  26. Neurosci Lett v.160 Apoptosis induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal coculture in rat MOchizuki, H;Nakamura, N;Nishi, K;Mizuno, Y
  27. J Herbology v.14 Neuroprotective effet of gastrodiae rhizoma on global ischemia induced by 4-vessel occlusion on rats Kim, H;Ahn, DK