Radiation Oncology Journal
- 제17권1호
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- Pages.1-8
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- 1999
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
두경부종양 환자에서 p53의 과발현과 방사선치료결과
P53 Overexpression and Outcome of Radiation Therapy in Head & Neck Cancers
- 김인아 (가톨릭대학교 의과대학 방사선종양학교실) ;
- 최일봉 (가톨릭대학교 의과대학 방사선종양학교실) ;
- 강기문 (가톨릭대학교 의과대학 방사선종양학교실) ;
- 장지영 (가톨릭대학교 의과대학 방사선종양학교실) ;
- 김경미 (가톨릭대학교 의과대학 임상병리과학교실) ;
- 박경신 (가톨릭대학교 의과대학 임상병리과학교실) ;
- 김영신 (가톨릭대학교 의과대학 임상병리과학교실) ;
- 강창석 (가톨릭대학교 의과대학 임상병리과학교실) ;
- 조승호 (가톨릭대학교 의과대학 이비인후과학교실) ;
- 김형태 (가톨릭대학교 의과대학 이비인후과학교실)
- Kim In Ah (Departments of Radiation Oncology, St. Mary's Hospital, College of Medicine, Catholic University) ;
- Choi Ihl Bhong (Departments of Radiation Oncology, St. Mary's Hospital, College of Medicine, Catholic University) ;
- Kang Ki Mun (Departments of Radiation Oncology, St. Mary's Hospital, College of Medicine, Catholic University) ;
- Jang Ji Young (Departments of Radiation Oncology, St. Mary's Hospital, College of Medicine, Catholic University) ;
- Kim Kyung Mi (Department of Clinical Pathology, St. Mary's Hospital, College of Medicine, Catholic University) ;
- Park Kyung Shin (Department of Clinical Pathology, St. Mary's Hospital, College of Medicine, Catholic University) ;
- Young Shin Kim (Department of Clinical Pathology, St. Mary's Hospital, College of Medicine, Catholic University) ;
- Kang Chang Suk (Department of Clinical Pathology, St. Mary's Hospital, College of Medicine, Catholic University) ;
- Cho Seung Ho (Department of Otolaryngology St. Mary's Hospital, College of Medicine, Catholic University) ;
- Kim Hyung Tae (Department of Otolaryngology St. Mary's Hospital, College of Medicine, Catholic University)
- 발행 : 1999.03.01
초록
목적 : 실험적으로 p53 종양억제유전자는 세포의 방사선에 대한 반응을 조절하는 것으로 알려져 있는데, 임상에서 p53의 변화와 방사선치료 후의 예후와의 상호관련성은 아직 명확하게 규명되지 않은 상태이다. 이에 두경부종양환자에서 흔히 관찰되는 p53의 변화가 방사선치료결과에 어떤 영향을 미칠 수 있는지를 알아보고자 하였다. 재료 및 방법 : 두경부종양으로 진단되어 근치적 방사선치료를 받은 55명의 환자를 대상으로 임상결과를 후향적으로 분석하였다. 각 환자의 치료전 종양조직의 paraffin section을 human p53단백질에 대한 monoclonal antibody (D-07)로 면역조직화학염색하여 labeling Index (number of labelded nuclei/total number of counted nuclei x100)를 구하여, 임상결과와 연관지어 분석하였다. 결과 : 전체환자의 67.2
Purpose : Experimental studies have implicated the wild type p53 In cellular response to radiation. Whether altered p53 function can lead to changes in clinical radiocurability remains an area of ongoing study. This study was performed to investigate whether any correlation between change of p53 and outcome of curative radiation therapy in patients with head and neck cancels. Methods : Immunohistochemical analysis with a mouse monoclonal antibody (DO-7) specific for human p53 was used to detect to overexpression of protein in formalin fixed, paraffin-embedded tumor sample from 55 head and neck cancer patients treated with curative radiation therapy (median dose of 7020 cGy) from February 1988 to March 1996 at 51. Mary's Hospital. Overexpression of p53 was correlated with locoregional control and survival using Kaplan-Meier method. A Cox regression multi-variate analysis was peformed that included all clinical variables and status of p53 expression. Results : Thirty-seven (67.2