동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제10권1호
  • /
  • Pages.1-15
  • /
  • 1999
  • /
  • 1226-6396(pISSN)
  • /
  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

사향소합원(麝香蘇合元)이 Alzheimer's disease 모델 백서의 학습과 기억에 미치는 영향

The effects of Sahyangsohapwon on Learning and Memory of AD Rats using Morris water maze and Radial arm maze paradigm

  • 황의완 (경희대학교 한의과대학 신경정신과 교실)
  • Whang Wei-Wan (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Kyung Hee University)
  • 발행 : 1999.08.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The effects of Sahyangsohapwon on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed. In the learning trials of Morris water maze, all three groups were improved in learning capacity as trials were repeated, but the sham group showed more prominent improvement in learning compared with the control group(p<0.01). 2. In memory retention test of Morris water maze, the sham group marked more significant improvement statistically in memory retention compared with the control group(p<0.05). 3. In the learning of radial arm maze, the sham group shows better learning capacity significantly compared with the control group(p<0.05). With the experimental results above, Sahyangsohapwon can be supposed to have the improving effects on the learning and memory of AD rats induced by electronical injury of nbM.

키워드

참고문헌

  1. 精校黃帝內經靈樞 洪元植(編)
  2. 대한신경과학회지 v.3 no.1 神經科 영역에서의 痴매 박영춘
  3. 대한정신약물학회지 v.3 no.1 痴매의 원인과 治療 박종한
  4. 대한신경과학회지 v.3 no.1 정신과 영역에서의 痴매 이근후
  5. 啓明醫大論文集 v.16 no.3 Alzheimer병의 증상 한일우;곽동일
  6. 萬病回春 공延賢
  7. 中國醫學大系 中 11卷 濟生方 嚴用和
  8. 醫學入門(全五卷中二) 李천
  9. 太平惠民和劑局方 陳師文(等編)
  10. 陜西中醫 v.16 no.9 百家論醫, 老年性痴매從肝論治 李曉玲
  11. 上海中醫藥雜誌 v.3 매從痰治 張覺人
  12. 신경국소진단학 김진수(譯);피터 두스(著)
  13. 정신생물학 박만상
  14. 증상감별치료 이봉교
  15. 뇌와 지능 이철우;이진호
  16. 심리학 장현갑(외 7인)
  17. 原本東醫寶鑑 許浚
  18. 동의신경정신과학회지 v.9 no.1 Dementia of Alzheimer Type에 關한 韓醫學的 臨床硏究 김보균;현경철;김종우;황의완
  19. 대한정신약물학회지 v.2 no.1 Alzheimer씨 치매-개론 및 최신 경향- 김진수
  20. 신경정신의학 v.34 no.3 老人의 기능 상태 평가 박종한
  21. 계명의대논문집 v.16 no.3 Alzheimer병 신경병리학적 소견과 분자생물학적 연구동향 손윤경
  22. 대한의학협회지 v.37 no.7 노인성 치매-정의,분류 및 임상양상 우종인
  23. 신경정신의학 v.35 no.6 알츠하이머병의 말초생물학적 지표로서 혈청 Alpha-1-antichymotrypsin 우종인(외 2인)
  24. 신경정신의학 v.36 no.1 한국의 한 농촌 지역에 거주하는 老人에서의 痴매의 유병률 우종인(외 6인)
  25. 대한정신약물학회지 v.7 no.2 老人정신병의 藥物治療 윤도준
  26. 慶熙韓醫大論文集 v.21 no.1 調胃升淸湯이 Alzheimer’s disease 모델 백서의 학습과 기억에 미치는 영향 이웅석;황의완;김현택;박순권
  27. 대한정신약물학회지 v.8 no.1 에스트로젠과 알쯔하이머병 이종섭;김찬형
  28. 한국심리학회지 v.5 흰쥐의 내측중격핵 손상이 Morris 수중미로과제의 學習에 미치는 效果 정봉교(외 2인)
  29. 동의신경정신과학회지 v.9 no.1 형방지황탕이 Alzheimer’s disease 모델 백서의 학습과 기억에 미치는 영향 조윤숙;황의완;김현택;박순권
  30. 경희의학 v.12 no.2 치매에 대한 한의학적 임상연구 황의완;김종우;이조희;엄효진;이승기
  31. 中國養生學 劉占文
  32. 醫宗必讀 李中梓
  33. 景岳全書 張介賓
  34. 心-胸-神志病辨證論治 張明淮
  35. 辨證奇文全書 錢鏡湖
  36. 丹溪醫集 중 丹溪心法 朱震亨
  37. 石室秘錄(下) 陳士鐸
  38. Pathophysiology adaptation and alterations in function 4th edition Bullock, B.L.
  39. International review of Neurology v.33 Smythies, J.R.;Bradely, R.J.
  40. Clinical Neurology v.1 Swash, M.;Oxbury, J.
  41. Am J Psychiatry v.154 no.Sup.5 Practice Guideline for the Treatment of Patients With Alzheimer’s Disease and Other Demenitas of Late Life American Psychiatric Association
  42. Brain Res v.622 no.1;2 Galanin fails to alter both acquisition of a two trial per day water maze task and neurochemical markers of cholinergic or serotonergic neurons in adult rats Aspley, S.;Fone, K.C.
  43. Behavioral and Neural Biology v.28 Spatial memory in Rats; Time course of working memory and effect of anesthetics Beatty, W.W.;Schavalia, D.A.
  44. Behavioral and Neural Bilolgy v.46 Exponential decay of spatial memory of rats in a radial maze Bolhuis, J.J.;Bijlsma, S.;Ansmink, P.
  45. Neurology v.49 Evaluation of dementia$\cdot(/TEX>A systematic study of theusefulness of the American Academy of Neurology’s Practice Parameters Chui, H.;Zhang, Q.
  46. Brain Res. v.679 no.1 Anabolic androgenic steroid and adrenal steroid effects on hippocampal plasticity Clark, A.S.;Mitre, M.C.;Brinck-Johnsen, T.
  47. Brain Res v.572 no.1;2 Effects of nicotine on spatial memory deficits in rats with septal lesions Decker, M.W.;Majchzak, M.J.;Anderson, D.J.
  48. Brain Res. v.554 no.1;2 Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats Deupree, D.L.;Turmer, D.A.;Watters, C.L.
  49. J Pharmacol Exp Ther v.257 no.1 (+-)-cis-2-methy1-spiro(1, 3-oxathiolane-5, 3’) quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal medel of Alzheimer’s disease Fisher, A.;Brandeis, R.;Karton, I.;Pittel, Z.;Gurwitz, D.;Haring, R.;Sapir, M.;Levy, A.;Heldman, E.
  50. pediatr Res. v.39 no.1 Use of the Morris water maze and acoustic startle chamber to evaluate neurologic injury after asphyxial arrest in rats Hickey, R.W.;Akino, M.;Strausbaugh, S.;De Courtmn-MyersGM
  51. Peptides v.10 no.1 TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesined rats Horita, A.;Carino, M.A.;Zabawska, J.;Lai, H.
  52. N Eng J Med v.314 Alzheimer’s disease Katzman, R.
  53. FASEB J. v.5 advances in Alzheimer’s disease Katzman, R.;Saitoh, T.
  54. Behavioral and Neural Biology v.44 Hippocampal stimulation disrupts spatial working memory even 8th after acquisition Knowlton, B.;McGowan, M.;Olton, D.S.
  55. J Pharmacol Exp Ther v.271 no.2 Studies on the role of K+, Cl- and Na+ ion permeabilities in the acetylcholine release enhancing effects of linopirdine (DuP 996) in rat cortical slices Maciag, C.M.;Logue, A.R.;Tinker, W.J.;Saydoff, J.A.;Tam, S.W.;Zacz다, R.
  56. Psycho phamacology v.106 Oxiracetam antagonizes the disruptive effects of scopolamine on memory in the radial maze Magnani, M.;Pozzi, O.;Biagetti, R.;Banfi, S.;Dorigotti, L.
  57. Neuroscience v.50 no.1 Dopaminergic drug reverse the impairment of radialarm maze performance caused by lesions involving the cholinergic medial pathway McGurt, S.R.;Levin, E.D.;Butcher, L.L.
  58. Neurology v.34 Clinical diagnosis of Alzheimer’s disease: report of the NINCDSADRDAWork Groupe under the auspices of Department of Health and Human Service Task Force on Alzheimer’s disease McKhann, G.;Drachman, D.;Folstein, M.;Katzman, R.;Price, D.;Stadlan, E.M.
  59. Neuroscience v.51 no.1 Evidence for a role of the neuropeptide galanin in spatial learning [Letter] Ogren, S.O.;Hokfelt, T.;Kask, K.;Langel, U.;Bartfai, T.
  60. American psychologist v.34 Mazes, maps and memory Olton, D.S.
  61. Animal Learning and Behavior v.7 Intramaze cues and “odortrials” fail to direct choice behavior on an elevated maze Olton, D.S.;Collison, C.
  62. The Journal of Family Practice v.37 no.6 Advances in Alzheimer’s disease Roth, M.E.
  63. Brain Res. v.494 no.2 The role of the hippocampal-nucleus accumbens pathway in radialarm maze performance Schacter, G.B.;Yang, C.R.;Innis, N.K.;Mogensin, G.J.
  64. J Pharmacol Exp Ther v.280 no.2 Pharmacological activity and safety profile of P10358, a novel, orally active acetycholine sterase inhibitor for Alzheimer’s disease Smith, C.P.;Bores, G.M.;Petko, W.;Li, M.;Selk, D.E.;Rush, D.K.;Camacho, F.;Winslow, J.T.;Fishkin, R.;cunningham, D.M.;Brooks, K.M.;Roehr, J.;Hartman, H.B.;Davis, L.;Vargas, H.M.
  65. Brain Res. v.582 no.2 Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats Torre, J.C.;Fortin, T.;Park, G.A.;Butler, K.S.;Kozlowski, P.;Pappas, B.A.;de-Socarraz, H.;Saunders, J.K.;Richard, M.T.
  66. Brain Res. v.589 no.2 Early post-natal administration of 5.7-dihy-droxytrypatamine destroys 5-HT neurons but does not affect spatial memory Volpe, B.T.;Hendrix, C.S.;Park, D.H.;Towle, A.C.;Davis, H.P.
  67. Brain Res v.726 no.1;2 Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and does-dependent working memory deficits Walsh, T.J.;Herzog, C.D.;Gandhi, C.;Stackman, R.W.;Wiley, R.G.
  68. Brain Res v.702 no.1;2 Behavioral and neurobiological alterations induced by the immunotoxin 192-IgG-saporin:cholinergic and non-cholinergic effects following i.c.v. injection Walsh, T.J.;Kelly, R.M.;Dougherty, K.D.;Stackman, R.W.;Wiley, R.G.;Kutscher, C.L.
  69. Am J Public health v.77 The public health impact of Alzheimer’s disease Weiler, P.G.
  70. Branis res. v.654 Enhan cement of memory processing in an inhibitory avoidance and radial maze task by post-training infusion of bombesin into nucleus tractus solitarius Cedric, L. Williams;James, L. McGaugh
  71. J Pharmacol Exp Ther v.272 no.1 FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze Yamazaki, M.;Matsuoka, N.;Kuratani, K.;Ohkubo, Y.;Yamaguchi, I Ibaraki
  72. J Cereb Blood Flow Metab v.16 no.5 Spatial memory disturbance after focal cerebral ischemia in rat Yonemori, F.;Yamada, H.;Yamaguchi, T.;Uemura, A.;Tamura, A.