대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

활락단(活絡丹)이 항염(抗炎), 진통(鎭痛) 및 항혈전(抗血栓)에미치는 영향(影響)에 대(對)한 연구(硏究)

Study on the Anti-inflammatory, Analgesic and Anticoagulative effects of Whalrakdan in the experimental animals

  • 강승범 (원광대학교 한의과대학 심계내과학 교실) ;
  • 박종운 (원광대학교 한의과대학 심계내과학 교실) ;
  • 김종길 (원광대학교 한의과대학 심계내과학 교실) ;
  • 조남수 (원광대학교 한의과대학 심계내과학 교실) ;
  • 문병순 (원광대학교 한의과대학 심계내과학 교실)
  • Kang, Seung-Bum (Dept. of Oriental Medicine, Graduate School of Won kwang University) ;
  • Park, Jong-Woon (Dept. of Oriental Medicine, Graduate School of Won kwang University) ;
  • Kim, Jong-Gil (Dept. of Oriental Medicine, Graduate School of Won kwang University) ;
  • Jo, Nam-Soo (Dept. of Oriental Medicine, Graduate School of Won kwang University) ;
  • Moon, Byung-Soon (Dept. of Oriental Medicine, Graduate School of Won kwang University)
  • 발행 : 1999.09.29
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was designed to elucidate the anti-inflammatory, cardiovascular, anti-thrombotic, and analgesic effect of Whalrakdan. The anti-inflammatory effects was measured by the method of carrageenin induced edema, protein leakage test using CMC-pouch, and the effect of Whalrakdan on the cardiovascular system was observed by the change of flow rate of Ringer solution in the vascular system in the ear of rabbit. and the contraction and dilatation of rat tail artery. Death rate, platelet aggregation, plasma coagulation activity, antithrombin activity was observed for the measurement of the anti-thrombotic effect of Whalrakdan, and the analgesic effect was measured by the acetic acid method and hot plate method. The result was as follows: 1. After 2 or 3hour of Whalrakdan administration, carrageenin induced edema and CMC-pouch protein leakage was significantly decreased. 2. The slight anagesic effect of Whalrakdan extract was confirmed by the observation of writhing syndrome, paw licking time, and escape time. 3. The droplet of Ringer solution increased according to the increase of concentration of Whalrakdan extract, and the vasoconstriction decreased dependantly to the concentration of Whalrakdan extract. 4. The anti-thrombotic effect of Whalrakdan was observed by the decrease of death rate, the inhibition of platelet aggregation, and the increase of anti-thrombin activity.

키워드

참고문헌

  1. 黃帝內經 洪元植
  2. 中醫內科學 v.香淃 上海中醫學院
  3. 千金要翼方 v.香淃 孫思邈
  4. 丹溪心法 朱震亨
  5. 醫學入門 이정
  6. 景岳全書 張介賓
  7. 奇效良方 v.香淃 方賢
  8. 儒門事親 張子和
  9. 證治準繩 王肯堂
  10. 大韓韓醫學會誌 v.11 no.1 痺證治療의 用藥에 관한 小考 姜仁守
  11. 東醫寶鑑 許浚
  12. 醫宗必讀 李中梓
  13. 萬病回春 공정현
  14. 類經 張介賓
  15. 中醫內科辨證學 王顯明
  16. 大韓韓醫學會誌 v.16 no.1 痺病의 文獻的 硏究 정석회
  17. 中醫診斷學 鄭鐵濤
  18. 血瘀證的診斷和治療 兪芝江
  19. 中醫內科學 杜英傑
  20. 中醫病因耭學 安鷺빙
  21. 天眞處方解說 李尙仁
  22. 臨床本草學 辛民敎
  23. J. Pharma. Soc. Korea v.19 chemistry and pharmacology of diterpenoids of Siegesbeckia pubescens Han, K.D.;Kim, J.H.;Oh, S.J.
  24. Shoyakugaku Zasshi v.39 Inhibition of metyrapone and heat-stresss induced hypertension by Phellodendti Cortex Kuzuo, A.;Yasuo, O.;C, J.C.
  25. 부산대논문집 v.18 상기생의 순환기계 약리학적 연구 洪村風幸
  26. 藥理學實驗法 田村風幸
  27. 藥效の評價(I) 津田恭介;野上 壽
  28. J. Pharm. Pharmacol. v.21 A perfused tail artery preperation from the rat Nicholas, T.E.
  29. J. Pharmacol. Exp. Therap. v.225 Mouse antithrombotic assay : A simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by alcohol Dimino, G.;Silver, M.J.
  30. Tromb. Res. v.52 Comparison of hirudin and hirudin PA C-terminal fragments and related analogs as antithrombin agents Krstenansky, J.L.;Mao, S.J.T.
  31. J. Phsiol. v.168 the aggregation of blood platelets Born, G.C.R.;Cross, M.J.
  32. Prostaglandins v.32 Effect of prostaglandins and arachidonic acid on baboon cerebral and mesenteric arteries Hayashi, S.;Park, M.K.
  33. Yakugaku Zasshi v.88 Studies on the mode of action of anti inflammatory agents I.Quantitative analysis of anti-inflammatory effect by carboxylmethyl cellulose pouch method Ishikawa, H.;Ninobe, S.;Tsurufuji, S.
  34. Hypersensistivity reactions in the experimental foundations of mordern immunology Clark, W.R.
  35. Investigation of delayed hypersensitivity in man in Immunology Revillard, J.P.
  36. J. Med. v.54 The classification of vasculitidies and a reappraisal of allergic granulomatosis and angitisMt. Sinai. Lie, J.T.
  37. Pathol. Annu. v.23 no.II Thromboangitis revisted Lie, J.T.
  38. Thromb Hemost. v.13 Thrombomodulin. Semin. Esmon, N.L.
  39. Thromb. Hemost. v.13 Anticoagulantly active heparin sulfate proteoglycan and the vascular endothelium. Semin. Marcum, J.A.;Rosenberg, R.D.
  40. Thromb. Hemost. v.13 Fibrinolytic pathways and the lendothelium. Semin Hekman, C.A.;Loskutoff, D.J.
  41. Rev. Med. v.31 The endothelium and thrombosis Annu. Wall, R.T.;Harker, L.A.