Applied Biological Chemistry
- Volume 42 Issue 3
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- Pages.205-209
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- 1999
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- 2468-0834(pISSN)
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- 2468-0842(eISSN)
Effect of Cholesterol in Liposome on the Stabilization of Encapsulated Ascorbic Acid
리포솜 내의 콜레스테롤 함량이 Ascorbic Acid의 안정성에 미치는 영향
- Rhim, Chae-Hwan (Division of Fine Chemistry and Chemical Engineering, Kyungnam University) ;
- Lee, Yu-Weon (Division of Life Sciences, Kyungnam University) ;
- Lee, Sang-Chun (Division of Fine Chemistry and Chemical Engineering, Kyungnam University) ;
- Lee, Seung-Cheol (Division of Life Sciences, Kyungnam University)
- Published : 1999.08.31
Abstract
Cholesterol plays an important role in various physiological responses and membrane stability. To investigate the effect of cholesterol in liposome on the stability of encapsulated ascorbic acid, the physico-chemical experiments using various amounts of cholesterol-containing liposomes were performed. The encapsulation efficiency of ascorbic acid was decreased with increasing cholesterol content in liposome, whereas size of liposome was increased. Furthermore, the stability of encapsulated ascorbic acid was increased with increasing the content of cholesterol. The stability was not affected by pH. Encapsulated ascorbic acid in liposome stored at
리포솜을 구성하는 지질 내의 콜레스테롤 함량이 포집된 ascorbic acid의 안정성에 미치는 영향을 조사하였다. 리포솜 내에서의 콜레스테롤 함량이 증가할수록 탈수화/재수화법으로 제조된 리포솜의 크기는 증가하였으며, 가해진 ascorbic acid의 안정성은 증대되었으며, 외부의 pH 영향을 크게 받지 않았다. 그러나,