Korean Journal of Pharmacognosy (생약학회지)
- Volume 30 Issue 4
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- Pages.413-416
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- 1999
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Inhibitory Effect of Coumarins on Nitric Oxide Production in LPS-Activated Murine Macrophages
쿠마린에 의한 RAW 264.7 세포주의 Nitric Oxide 생성 저해활성
- Rho, Tae-Cheol (Korea Research Institute of Bioscience & Biotechnology) ;
- Choi, Hee-Cheol (Korea Research Institute of Bioscience & Biotechnology) ;
- Kim, Bo-Yeon (Korea Research Institute of Bioscience & Biotechnology) ;
- Kim, Young-Ho (College of Pharmacy, Chungnam National University) ;
- Ahn, Jong-Seog (Korea Research Institute of Bioscience & Biotechnology) ;
- Kim, Young-Kook (Korea Research Institute of Bioscience & Biotechnology) ;
- Lee, Hyun-Sun (Korea Research Institute of Bioscience & Biotechnology)
- 노태철 (생명공학연구소) ;
- 최희철 (생명공학연구소) ;
- 김보연 (생명공학연구소) ;
- 김영호 (충남대학교 약학대학) ;
- 안종석 (생명공학연구소) ;
- 김영국 (생명공학연구소) ;
- 이현선 (생명공학연구소)
- Published : 1999.12.30
Abstract
During the screening for inhibitors on nitric oxide (NO) production in LPS-activated murine macrophage, RAW 264.7 cells, two coumarins were isolated from chloroform extract of Ponciri Fructus. They were identified as imperatorin (10), phellopterin (11) on the basis of spectroscopic methods. The