Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Isolation and Quantitative Determination of Berberine and Coptisine from Tubers of Corydalis ternata

들현호색으로부터 Berberine과 Coptisine의 분리 및 함량분석

  • Lee, Hyang-Yi (College of Pharmacy, Catholic University of Taegu-Hyosung) ;
  • Kim, Chong-Won (College of Pharmacy, Catholic University of Taegu-Hyosung)
  • 이향이 (대구효성가톨릭대학교 약학대학) ;
  • 김종원 (대구효성가톨릭대학교 약학대학)
  • Published : 1999.09.30
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Abstract

Corydalis Tuber has been used in traditional medicine for an analgesic, antispasmodic and gastric ulcers. For the quality control on this drug, isolation and quantitative determination of berberine and coptisine from Corydalis ternata Nakai (Papaveraceae) has been conducted by using HPLC method. Berberine and coptisine in quarternary alkaloidal fraction from the crude drug were separated on silicagel column using a $CHCl_3:MeOH\;(85:15)$ and $CHCl_3:MeOH:H_2O\;(70:30:4)$ as an eluent, and the average contents were about 0.93 and 0.36%.

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