Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Some Plant Extracts for Inhibitory Activities on Hepatitis B Virus Replication

수종 생약재의 간염 B형 바이러스 증식 억제 활성 검색

  • Kim, Tae-Gyun (Division of Biochemical Pharmacology, National Institute of Toxicological Research) ;
  • Han, Hyung-Mee (Division of Biochemical Pharmacology, National Institute of Toxicological Research) ;
  • Kang, Seog-Youn (Division of Biochemical Pharmacology, National Institute of Toxicological Research) ;
  • Jung, Ki-Kyung (Division of Biochemical Pharmacology, National Institute of Toxicological Research) ;
  • Kim, Seung-Hee (Division of Biochemical Pharmacology, National Institute of Toxicological Research)
  • 김태균 (국립독성연구소 생화학약리과) ;
  • 한형미 (국립독성연구소 생화학약리과) ;
  • 강석연 (국립독성연구소 생화학약리과) ;
  • 정기경 (국립독성연구소 생화학약리과) ;
  • 김승희 (국립독성연구소 생화학약리과)
  • Published : 1999.09.30
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Abstract

This study was undertaken to test for anti-hepatitis B virus (HBV) activity of the aqueous extracts prepared from 9 medicinal plants of Korea (Cornus officinalis, Caesalpinia sappan, Rubus coreanus, Lycium chinense, Artemisia capillaris, Isatis tinctoria, Phyllanthus urinaria, Lysimachia christinae, Lonicera japonica). Aqueous extracts were tested for cytotoxicity and assayed for inhibition of HBV replication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium f HepG2 2.2.15 cells. The extract from Rubus coreanus, Artemisia capillaris, Phyllanthus urinaria decreased the levels of extracellular HBV virion DNA at concentrations ranging from 128 to $256\;{\mu}g/ml$ and inhibited the production fo HBsAg dose-dependently without showing cytotoxicity. Our findings suggest that these three hebal medicinal plants may have potential to develop as specific anti-HBV drugs in the future.

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