Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Cumambrin A Treatment on Blood Pressure in Spontaneously Hypertensive Rats

고혈압 흰쥐에서 Cumambrin A의 혈압 강하 효과

  • Hong, Yong-Geun (Department of Biochemistry and Cardiovascular Research Institute, Gyeongsang National University) ;
  • Yang, Min-Suk (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Pak, Yun-Bae (Department of Biochemistry and Cardiovascular Research Institute, Gyeongsang National University)
  • 홍용근 (경상대학교 자연과학대학 생화학과, 심혈관연구소) ;
  • 양민석 (경상대학교 농과대학 농화학과) ;
  • 박윤배 (경상대학교 자연과학대학 생화학과, 심혈관연구소)
  • Published : 1999.06.30
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Abstract

We have isolated a sesquiterpene lactone, cumambrin A from the dried flowers of Chrysanthemum boreale Makino and reported its chemical structure. The aim of the present study was to investigate whether the exogenous administration of cumambrin A has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In vitro studies: Relaxative response induced by cumainbrin A was increased with dose-dependent manner and showed maximizing response at a concentration of $5{\times}10^{-4}M$. Further, this relaxative response was significantly increased at a condition of endothelium present than that of endothelium denuded. In vivo studies: The normalizing effect of cumambrin A on blood pressure was also increased with time-dependent manner and then gradually recovered to normal condition at approximately 4 hrs after cumambrin A treatment.

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