Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Biological Activities of Sesquiterpene Lactones isolated from Several Compositae Plants. Part 2 -FPTase Inhibitory Activity-

수종의 국화과 식물에서 분리한 Sesquiterpene Lactone들의 생리활성(제2보) -FPTase 저해활성-

  • Jang, Dae-Sik (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Kwon, Byong-Mog (Korea Research Institute of Bioscience & Biotechnology (KRIBB)) ;
  • Yang, Min-Suk (Department of Agricultural Chemistry, Gyeongsang National University)
  • Published : 1999.03.30
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Abstract

Nine sesquiterpene lactones, which were isolated from Hemisteptia lyrata Bunge. Chrysanthemum zawadskii Herbich var. latilobum Kitamura and Chrysanthemum boreale Makino were evaluated for the farnesyl-protein transferase (FPTase) inhibitor, conducted by the scintillation proximity assay (SPA). The angeloylcumambrin B and tigloylcumambrin B inhibited a recombinant rat FPTase with $IC_{50}$ value of $78\;{\mu}g/ml$ $(225\;{\mu}M)$ and $90\;{\mu}g/ml$ $(260 \;{\mu}M)$, respectively.

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