The Korean Journal of Physiology and Pharmacology
- 제3권6호
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- Pages.571-578
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- 1999
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Effects of Protein Kinase C Modulation on Hepatic Hemodynamics and Glucoregulation
- Lee, Joong-Woo (Department of Physiology and Institute of Medical Engineering, Yonsei University, Wonju College of Medicine) ;
- Kong, In-Deok (Department of Physiology and Institute of Medical Engineering, Yonsei University, Wonju College of Medicine) ;
- Park, Kyu-Sang (Department of Physiology and Institute of Medical Engineering, Yonsei University, Wonju College of Medicine) ;
- Chung, Hae-Sook (Department of Physiology and Institute of Medical Engineering, Yonsei University, Wonju College of Medicine) ;
- Filkins, James P. (Department of Physiology, Stritch School of Medicine, Loyola University of Chicago)
- 발행 : 1999.12.21
초록
This study evaluated the effects of PKC activation using phorbol 12-myristate 13-acetate (PMA) and PKC inhibition using the isoquinoline sulfomide derivative H-7 on hemodynamics and glucoregulation in the isolated perfused rat liver. Livers were isolated from fed male Holtzman rats and perfused with Krebs Ringer bicarbonate solution under a constant flow of 50 ml/min at