The Korean Journal of Physiology and Pharmacology
- 제3권5호
- /
- Pages.513-519
- /
- 1999
- /
- 1226-4512(pISSN)
- /
- 2093-3827(eISSN)
Changes in Phosphate Transporter Activity Evaluated by Phosphonoformic Acid Binding in Cadmium-Exposed Renal Brush-Border Membranes
- Chung, Jin-Mo (Department of Physiology, Kosin Medical College) ;
- Ahn, Do-Whan (Department of Physiology, Kosin Medical College) ;
- Kim, Kyoung-Ryong (Department of Physiology, Kosin Medical College) ;
- Park, Yang-Saeng (Department of Physiology, Kosin Medical College)
- 발행 : 1999.10.21
초록
Direct exposure of renal tubular brush-border membranes (BBM) to free cadmium (Cd) causes a reduction in phosphate (Pi) transport capacity. Biochemical mechanism of this reduction was investigated in the present study. Renal proximal tubular brush-border membrane vesicles (BBMV) were isolated from rabbit kidney outer cortex by Mg precipitation method. Vesicles were exposed to