The Korean Journal of Physiology and Pharmacology
- 제3권5호
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- Pages.471-479
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- 1999
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Decreased Voltage Dependent $K^+$ Currents in Cerebral Arterial Smooth Muscle Cells of One-Kidney, One-Clip Goldblatt Hypertensive Rat
- Oh, Young-Sun (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Se-Hoon (Department of Physiology, College of Medicine, Konyang University) ;
- Kim, Hoe-Suk (Department of Physiology, College of Medicine, Chungnam National University) ;
- Jeon, Byeong-Hwa (Department of Physiology, College of Medicine, Chungnam National University) ;
- Chang, Seok-Jong (Department of Physiology, College of Medicine, Chungnam National University) ;
- Kim, Kwang-Jin (Department of Physiology, College of Medicine, Chungnam National University)
- 발행 : 1999.10.21
초록
The Kv channel activity in vascular smooth muscle cell plays an important role in the regulation of membrane potential and blood vessel tone. It was postulated that increased blood vessel tone in hypertension was associated with alteration of Kv channel and membrane potential. Therefore, using whole cell mode of patch-clamp technique, the membrane potential and the 4-AP-sensitive Kv current in cerebral arterial smooth muscle cells were compared between normotensive rat and one-kidney, one-clip Goldblatt hypertensive rat (lK,lC-GBH rat). Cell capacitance of hypertensive rat was similar to that of normotensive rat. Cell capacitance of normotensive rat and 1K,lC-GBH rat were