The Korean Journal of Physiology and Pharmacology
- 제3권3호
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- Pages.283-291
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- 1999
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Selective Cytotoxicity of a Novel Platinum (II) Coordination Complex on Human Gastric Cancer Cell Lines and Normal Kidney Cells
- Jung, Jee-Chang (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
- Kim, Young-Kyu (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
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Yim, Sung-Vin
(Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
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Park, Seung-Joon
(Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
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Chung, Joo-Ho
(Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
- Chang, Sung-Goo (Departments of Urology, School of Medicine, Kyung Hee University) ;
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Lee, Kyung-Tae
(Department of Biochemistry, College of Pharmacy, Kyung Hee University) ;
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Rho, Young-Soo
(Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University)
- 발행 : 1999.06.21
초록
We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DPPE)]