Journal of Oriental Physiology (동의생리학회지)
- Volume 14 Issue 2 Serial No. 20
- /
- Pages.199-208
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- 1999
Effects of Chilbokyeum on the Cerebral Cortex Neuron injured by Glucose Oxidase
칠복음(七福飮)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)
- Choi, Kong-Han (Dept. of Psycology, College of Oriental medicine, Wonkwang Univ.) ;
-
Park, Seung-Taeck
(Dept. of Anatomy, College of medicine, Wonkwang Univ.) ;
- Ryu, Do-Gon (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Choi, Min-Ho (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Um, Sang-Sub (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Hea, Jin-Young (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Kang, Sung-Do (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Go, Jeong-Soo (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Sou, Eui-Suk (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Sung, Yeun-Kyung (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Cho, Nam-Su (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Lee, Chun-Woo (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Whang, Il-Taeck (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Sun, Sung-Kyu (Dept. of Physiology, College of Oriental medicine, Wonkwang Univ.) ;
- Ryu, Young-Su (Dept. of Psycology, College of Oriental medicine, Wonkwang Univ.)
- 최공한 (원광대학교 한의과대학 정신과교실) ;
-
박승택
(원광대학교 의과대학 해부학교실) ;
- 류도곤 (원광대학교 한의과대학 생리학교실) ;
- 최민호 (원광대학교 한의과대학 생리학교실) ;
- 엄상섭 (원광대학교 한의과대학 생리학교실) ;
- 허진영 (원광대학교 한의과대학 생리학교실) ;
- 강성도 (원광대학교 한의과대학 생리학교실) ;
- 고정수 (원광대학교 한의과대학 생리학교실) ;
- 서의석 (원광대학교 한의과대학 생리학교실) ;
- 성은경 (원광대학교 한의과대학 생리학교실) ;
- 조남수 (원광대학교 한의과대학 생리학교실) ;
- 이춘우 (원광대학교 한의과대학 생리학교실) ;
- 황일택 (원광대학교 한의과대학 생리학교실) ;
- 선성규 (원광대학교 한의과대학 생리학교실) ;
- 류영수 (원광대학교 한의과대학 정신과교실)
- Published : 1999.09.01
Abstract
As the average life span have been lengthened and the rate of senile population have been raised, chronic degenerative diseases incident to aging has been increased rapidly and become a social problem. With this social background, recently, the facts that oxygen radicals(OR) have toxic effects on Central Nervous System and Peripheral Nervous System and cause neuropathy such as Parkinson's Disease, Alzheimer Disease have been turned out, and accordingly lots of studies on the mechanism of the toxic effects of OR on nerves, the diseases caused by OR and the approaches to curing the diseases have been made. The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Chilbokyeum(CBY) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay 2. GO, a oxygen radical, increased lipid peroxidation and the amount of LDH. 3. CBY have efficacy of decreasing lipid peroxidation. 4. CBY have efficacy of decreasing the amount of LOH. From the above results, It is concluded that Chilbokyeum has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And Chilbokyeum is thought to have certain pharmacological effects on controlling over aging and treating Dementia. Further clinical study of this pharmacological effects of Chilbokyeum should be complemented.