The Journal of Dong Guk Oriental Medicine (동국한의학연구소논문집)
- Volume 7 Issue 1
- /
- Pages.75-86
- /
- 1998
- /
- 1226-556X(pISSN)
Anti-diabetic effect and effect on glucose-phosphorylase activities of the leaf of Eriobotryae folium on diabetes mellitus mice induced by interleukin-1β
비파엽(枇杷葉)의 항당뇨병약리활성(抗糖尿病藥理活性)과 IL-1β유발당뇨병(誘發糖尿病) 마우스의 췌장(膵臟) 인산화효소(燐酸化酵素)에 미치는 효과(效果)에 관(關)한 연구(硏究)
- Yoon, Cheol-Ho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
- Jeong, Ji-Cheon (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
- Kim, Cheorl-Ho (Department of Biochemistry ana Molecular Biology, College of Oriental Medicine, Dongguk University)
- Published : 1998.08.31
Abstract
Studies were conducted on anti-dibetic effect of the water extract from leaves of Eriobotryae folium, which had been used in Korea as a remedy for dibetes. The extract was found to inhibit the increase in the plasma level of sugar bu the not the decrease in the plasma level of insulin in alloxan-induced dibetic rats. Also, we investigated the in vivo effect of an aqueous extract (referred to as EF) from Eriobotryae folium on glucokinase and hexokinase activities of diabetes mellitus induced by interleukin-
청양생진(淸凉生津), 해갈지구(解渴止嘔)의 효능이 있으며, 한국등에서 항당뇨병성 한약으로서 사용되어 온 비파엽의 열수출물의 당뇨병치료효과를 검증하기 위하여 alloxan으로 유발된 당뇨병흰쥐의 혈장포도당농도 및 인슈린농도를 측정하였다. 비파엽처리군의 혈장 포도당농도는 현저히 증가하였으며 혈장인슈린농도는 크게 감소하지 않았다. 한편, 당뇨병유발의 내재적인 요소로 알려진 사이토카인인
Keywords