The Effects of Gobongeonyangdan on the sex hormones and hematogenesis in rats

고본건양단(固本健陽丹)이 백서(白鼠)의 성(性)호르몬 및 조혈기능(造血機能)에 미치는 영향(影響)

It has been known that "Gobongeonyangdan" has a certain effects on male sterility in the field of oriental medicine. This thesis purposes to prove such effects of the medicine especially concerning sex hormones and hematogenesis. In the study were used three groups of rats: two of those were treated with Gobongeonyangdan with a variety of quantity and the other untreated. The experiment spans for 35 days: tests upon those subjects were done three times on the 7th, 21st, and 35th day checking the change of testosterone, estradiol, LH, FSH and iron in the serums, and RBC, hematocrit and hemoglobin levels. The results obtained from the study are as follows: 1. The content of testosterone in the serums marked a significant increase in both treated groups in comparison to the untreated group. 2. The content of estradiol in the serums showed a significant increase in the treated groups as to the untreated. 3. The content of LH in the serums increased significantly in the treated groups as to the untreated. 4. The content of FSH in the serums also increased remarkably in the two treated groups as to the untreated. 5. The content of iron in the serum was seen to be increased in the treated groups rather than the untreated group. 6. The RBC was observed to show a tendency toward a significant increase in both the treated groups in comparison with the untreated group. 7. The hemoglobin levels were also increased significantly in the treated groups as to the untreated. 8. The hematocrit levels were decreased significantly in one of the two treated group(sample A group) and there was no difference in the other group(sample B group) in comparison with the untreated group. Consequently, "Gobongeonyangdan" may well be a favorable medicine for patients two have sexual functional disorder and it is also effective on hematogenesis.