YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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The Inhibitory Effects of Taraxaci Herba against Cadmium induced Cytotoxicity

포공령의 카드뮴에 대한 세포독성 억제효과

  • Han, Du-Seok (Department of Oral Anatomy, School of Dentistry) ;
  • Lee, Ki-Nam (Department of Preventive Medicine, School of Oriental Medicine) ;
  • Lee, Jong-Sub (Department of Preventive Medicine, School of Medicine) ;
  • Baek, Seung-Hwa (Department of Chemistry, College of Natural Sciences, Wonkwang University)
  • 한두석 (원광대학교 치과대학 구강해부학교실) ;
  • 이기남 (한의과대학 예방의학교실) ;
  • 이종섭 (의과대학 예방의학교실) ;
  • 백승화 (자연과학대학 화학과)
  • Published : 1998.06.01
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Abstract

This study was carried out to evaluate antitoxic effects Taraxaci Herba extract against Cadium by calorimetric methods. The antitoxic activity of Taraxaci Herba ex tract in NIH 3T3 fibroblasts was evaluated by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-phenyl-2H-tetrazoliumbromide), NR (Neutral red) and SRB (Sulforhodamine B protein) assay. The light microscopic study was carried out to observe morphological changes of the treated cells. These results were obtained as follows; The concentration of $10^{-2}mg/ml$ of Taraxaci Herba extract was shown significant antitoxic activity. The number of NIH 3T3 fibroblasts were antitoxic and tend to regenerate. These results suggest that Taraxaci Herba extract retains a potential antitoxic activity.

Keywords

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