약학회지 (YAKHAK HOEJI)

  • 제42권6호
  • /
  • Pages.607-612
  • /
  • 1998
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

무청으로부터 분리된 이소람네틴 3-O-beta-D글루코피라노사이드의 항헤르페스 바이러스 1형(HSV-1) 효과

Anti-Herpes Simplex Virus type I (HSV-1) Effect of Isorhamnetin 3-0-beta-D-Glucopyranoside Isolated from Brassica rapa

  • Kim, Ho-Kyoung (Department of Research, Korea Institute of Oriental Medicine) ;
  • Kang, Bong-Joo (Department of Research, Korea Institute of Oriental Medicine) ;
  • Park, Kap-Joo (Department of Research, Korea Institute of Oriental Medicine) ;
  • Ko, Byoung-Seob (Department of Research, Korea Institute of Oriental Medicine) ;
  • Whang, Wann-Kyun (College of Pharmacy, Chungang University)
  • 발행 : 1998.12.01
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초록

In the course of our search for anti-Herpes simplex virus type I (HSV 1) substances from natural sources, we screened crude drugs for their antiviral activity using SRB assay. T he methanol extract from herb of Brassica rapa (Cruciferae) was found to inhibit HSV-1. Though bioassay-directed fractionation of the extract, anti-HSV-1 agent was isolated by chromatographic separation using Amberlite XAD-4 and Sephadex LH-20. The structure of compound I was elucidated by spectral means including $^1H-^1H$ COSY, HMQC and HMBC to be isorhamnetin 3-O-${\beta}$-D-glucopyranoside (compound I). Compound I was active against HSV-1 with the 50% effective concentration of O.42mg/ml and the 50% cytotoxicity of 5.0mg/ml.

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