YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Analgesic Constituent from the Herba of Saururus chinensis ($L_{OUR.})B_{AILL.}$

삼백초의 진통성분

  • Park, Si-Kyung (Central Research Institute, Samjin pharmaceutical Co., LTD) ;
  • Oh, Gab-Jin (Central Research Institute, Samjin pharmaceutical Co., LTD) ;
  • Kim, Hyun-Tae (Central Research Institute, Samjin pharmaceutical Co., LTD) ;
  • Kim, Hyun-Jong (Central Research Institute, Samjin pharmaceutical Co., LTD) ;
  • Chung, Sun-Gan (Central Research Institute, Samjin pharmaceutical Co., LTD) ;
  • Cho, Eui-Hwan (Central Research Institute, Samjin pharmaceutical Co., LTD)
  • 박시경 (삼진제약(주) 중앙연구소) ;
  • 오갑진 (삼진제약(주) 중앙연구소) ;
  • 김현태 (삼진제약(주) 중앙연구소) ;
  • 김현종 (삼진제약(주) 중앙연구소) ;
  • 정순간 (삼진제약(주) 중앙연구소) ;
  • 조의환 (삼진제약(주) 중앙연구소)
  • Published : 1998.06.01
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Abstract

For the investigation of bioactive natural products with analgesic activity, we have evaluated various extracts of Saururi Herba (Saururaceae), which has been used in traditiona l medicine for edema, beriberi, jaundice, turbid urine, carbuncle and furuncle. The diethylether extract of this plant was found to show a significant analgesic effect on writhing syndrome in mice. Using bioactivity-guided separation of the diethylether extract, analgesic constituent, (8S, 8`R, 7R, 6`R)-2'-oxo-4,5: 4',5'-bis(methylenedioxy)-${\Delta}^{1,3,5,3'}$-8.8', 7.6', 2.O.5'-neolignan(sauchinone) was isolated and structurally identified by physico-chemical properties and spectroscopic evidences. This compound has good analgesic activity with lower toxicity, as compared to other antipyretic-analgesic drug(acetaminophen).

Keywords

References

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