YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Cytotoxic Constituents of Rumex japonicus

참소리쟁이의 세포독성 성분

  • Kim, Dae-Keun (Natural Products Laboratory, College of Pharmacy, Woosuk University) ;
  • Choi, Sang-Un (Korea Research Institute of Chemical Technology) ;
  • Ryu, Si-Yong (Korea Research Institute of Chemical Technology) ;
  • Lee, Kang-Ro (Natural Product Laboratory, College of Pharmacy, Sung Kyun Kwan University) ;
  • Published : 1998.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Activity-guided fractionation and repeated column chromatography afforded two cytotoxic compounds R-3 and R-4 from the root of Rumex japonicus HOUTT. Compou nds were identified as musizin and emodin, respectively, by the physicochemical and spectral data. Besides R-3 and R-4, two compounds R-1 and R-2, chrysophanol and physcion, respectively, were also isolated. The compound R-3 and R-4 exhibited cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15 with $ED_{50}$ values ranging from 2.68 to $10.06{\mu}g/ml$.

Keywords

References

  1. 대한식물도감 이창복
  2. 중국본초도감 v.1 동국대학교 한의과대학 본초학회(번역)
  3. Resursyi Introduktsiya Polezn. Rast. Sibiri Flavonoids of Rumex L. species of the Holoapathum Losinsk. section Vysochina, G. I.;Gontar, E. M.
  4. Bot. Mag. v.99 Flavonoids in the leaves of twenty-eight polygonaceous plants Kawasaki, M.;Kanomata, T.;Yoshitama, K.
  5. Biochem. Syst. Ecol. v.21 Flavonoids and anthraquinones of some Egyptian Rumex species Saleh, N. A. M.;El-Hadidi, M. N.;Arafa, R. F. M.
  6. Egypt. J. Pharm. Sci. v.15 Anthraquinone content of certain Rumex species growing in Egypt Sayed, M. D.;Balbaa, S. I.;Afifi, M. S. A.
  7. Herba Hung v.14 Anthraquinones in some Rumex species Rada, K.;Hrochova, V.
  8. Pharmazie v.49 Anthraquinone derivatives in Rumex gracilescens and R. crispus. Demirezer, L. O.
  9. Phytochemistry v.11 Chemotaxonomy of anthraquinones in Rumex Fairbairn, J. W.;El-Muhradi, F. J.
  10. Opyt. Kul't. Nov. Syr' evykh Rast v.1 Chemotaxonomy of some middle-Asiatic Rumex species Sagatov, S. S.
  11. Plant Physiol. v.98 Carbon dioxide inhibits respiration in leaves of Rumex crispus. Amthor, J. S.;Koch, G. W.;Bloom, A. J.
  12. Haksul Yonguchi-Chugnam Taehakkyo, Chayon Kwahak Yonguso v.8 Atomic absorption spectrophotometric analysis of heavy metals accumulated in river bed soils and plants in Seoul area Koh, S. D.;Shin, C. N.
  13. Arch. Pharm. Res. v.15 Antiviral triterpenes from Prunella vulgaris Ryu, S. Y.;Lee, C. K.;Lee, C. O.;Kim, H. S.;Zee, O. P.
  14. Naturally occurring quinones(2nd ed.) Thomson, R. H.
  15. Shoyakugaku Zasshi v.41 Anthraquinone Components in Rumex acetosa Kato, T.
  16. Agric. Biol. Chem. v.46 Isolation of Hydroxyanthrones from the roots of Rumex acetosa Tamano, M.;Koketsu, J.
  17. Arch. Pharm. Res. v.18 Anthraquinone and Stilbene Derivatives from The Cultivated Korean Phubarb Rhizomes Ko, S. K.;Whang, W. K.;Kim, I. H.
  18. Spectrometric identification of organic compounds(5th ed.) Silverstein, R. M.;Bassler, G. C.;Morrill, T. C.
  19. J. Am. Oil Chem. Soc. v.68 Antioxidizing component, musizin, in Rumex japonicus Houtt Nishina, A.;Kubota, K.;Kameoka, H.;Osawa, T.