YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Isolation of Inhibitory Components on Tumor Necrosis Factor-${\alpha}$ Production from Angelica koreana

강활에서 종양괴사인자 생성을 억제하는 활성성분의 분리

  • 조재열 ((주)대웅제약 중앙연구소) ;
  • 이종수 ((주)대웅제약 중앙연구소) ;
  • 박지수 ((주)대웅제약 중앙연구소) ;
  • 박명환 ((주)대웅제약 중앙연구소)
  • Published : 1998.04.01
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Abstract

The total ethanol extract of Angelica koreana radix (UmbeUiferae) showed potent inhibitory effect on tumor necrosis factors (TNF-${\alpha}$) production from LPS-stimulated RAW 264.7 cells in screening studies on 118 Korean medicinal plants. The activity-guided fractionation of the total ethanol extract resulted in the isolation of 4 compounds, including active substances. The chemical structures of the compounds isolated were established by chemical and spectrometric analyses as imperatorin, isoimperatorin, osthol and oxypeucedanin. Among them, osthol, oxypeucedariin and isoimperatorin showed significant inhibitory activities on TNF-${\alpha}$ production as 54.3${\pm}$2.1%, 33.6${\pm}$1.0% and 17.7${\pm}$3.0%, respectively, at 12.5${\mu}$g/ml.

Keywords

References

  1. J. Biol. Chem. v.266 Tumor necrosis factor. New insights into the molecular mechanism of its multiple actions Vileek, J.;Lee, T.H.
  2. Drug News Perspect v.9 Pathophysiology and regulation of TNF-α in inflammation Sekuk, L.;Connolly, K.M.
  3. Tumor Necrosis Factors: The Molecules and their emerging role in medicine Beutler, P.B.
  4. In The Cytokine Handbook Tumor necrosis factor-α or cachectin Manogue, K.R.;Denventer, J.H.;Cerami, A.;Thomson, A.(ed.)
  5. In Pathophysiology of shock, sepsis and organ failure Hepatic dys-Function in shock and organ failure Bamkey, P.E.;Cerra, F.B.;Schlag, G.(ed.);Redl, H.(ed.)
  6. Prog. Clin. Biol. Res. v.367 The role of cachectin/TNF-alpha and other cytokines in sepsis Zentella, A.;Manogue, K.;Cerami, A.
  7. Biochem. Pharmacol. v.38 Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice Tiegs, G.;Wolter, M.;Wendel, A.
  8. In Rheumatology Rheumatoid synovitis and pannus Firestein, G.S.;Klippel, J.(ed.);Dieppe, P.(ed.)
  9. Science v.264 Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors Novgrodiski, A.;Vanichkin, A.;Patya, M.;Gazit, A.Osgerov, N.;Levitzki, A.
  10. J. Exp. Med. v.172 Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points n the signalling pathway Han, J.;Thompson, P.;Beutler, B.
  11. J. Exp. Med. v.177 Thalidomide exerts its inhibitory action on tumor necrosis factor-α by enhancing mRNA degradation Moreira, A.L.;Sampaio, E.P.;Zumuidzinas, A.;Frindt, P.;Smith, K.A.;Kaplan, G.
  12. Nature v.370 Regulation of tumour necrosis factor-α processing by a metalloprotenase inhibitor McGeehan, G.M.;Becherer, J.D.;Bast, R.C.;Biyer, C.M.;Champion, B.;Connolly, K.M.;Conway, J.G.;Furdon, P.;Karp, S.;Kidao, S.;McElroy, A.B.;Nochols, J.;Peyzwansky, K.M.;Shoenen, F.;Sekut, I.;Truesdale, A.;Verghese, M.;Warner, J.;Ways, J.P.
  13. J. Exp. Med. v.181 A metalloproteinase inhibitor blocks shedding of the 80-kd TNF receptor and TNF processing in T lymphocytes Crowe, P.D.;Walter, D.N.;Mohler, K.M.;Otten-Evans, C.;Black, R.A.;Ware, C.F.
  14. J. Immunol. v.151 Adenosine and a related carbocyclic nucleoside selectively inhibit tumor necrosis factor-α production and protect mice againgst endotoxin challenge Parmely, M.J.;Zhou, W.W.;Edwards, C.K.;Borcherding, D.R.;Silverstein, R.;Morrison, D.C.
  15. J. Pharmmacol. Exp. Ther. v.273 Spcific transcriptional inhibition of bone marrow-derived macrophage tumor necrosis factor-α gene expression and protein production using novel enantiomeric carboxylic nucleoside analorgues Bradshaw, M.;Rutherford, M.S.;Hoeper, B.J.;McWhinney, C.D.;Borcgerding, D.R.;Shook, L.B.;Edwards, C.K.
  16. J. Immunol. v.152 Protective effect of an adenosine kinase Ⅰ inhibitor in septic shock Firestein, G.S.;Boyle, S.D.;Bullogh, D.A.;Gruber, H.E.;Sajjadi, F.G.;Montag, A.;Sambol. B.;Mullane, K.M.
  17. J. Immunol. v.156 Inhibition of TNF-α expression by adenosine: Role of !2 adenosine receptors Sajjadi, F.G.;Takabayashi, K.;Foster, A.C.;Domingo, R.C.;Firestein, G.S.
  18. Biochem. Biophys. Res. Commun. v.226 Inhibition of the expression of inducible cycloxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases Hwang, D.;Fischer, N.H.;Jang, B.C.;Tak, H.;Kim, J.K.;Lee, W.
  19. Arch. Pharm. Res. v.21 Inhibitory effect of lignans from the rhizomes of Coptis japonica var. dissecta on TNF-α production in LPS-Stimulated RAW264.7 cells Cho, J.Y.;Park, J.;Yoo, E.S.;Yoshikawa, K.;Baik, K.U.;Lee, J.;Park, M.H.
  20. The Soring Comvention of Pharmaceutical Society of Korea, Abstr. Isolation and identification of inhibitory compounds on TNF-α production from Flos Magnolize Chae, S.H.;Kim, P.S.;Cho, J.Y.;Park, J.;Lee, J.H.;Yoo, E.S.;Baik, K.U.;Lee, J.;Park, M.H.
  21. Med. Inflamm. v.22 Inhibitory effects of bisbenzylisoguinolines on synthesis of the inflammatory cytokubes interleukin-1 and tumor necrosis factor-alpha Seow, W.K.;Nakamura, K.;Sugimura, Y.;Sugimoto, Y.;Yamada, Y.;Fairlie, D.P.;Thong, Y.H.
  22. Life Sci. v.50 Comparative effects of tetrandrine and berbamine on production of the inflammatory cytokines interleukin-1 and tumor necrosis factor-alpha Seow, W.K.;Ferrante, A.;Summors, A.;Thong, Y.H.
  23. Planta Med. v.61 Inhibitory effects of bisbezylisoquinoline alkaloids on induction of proinflammatory cytokines, interleukin-1 and tumor necrosis factor-α Onai, N.;Tsunokawa, Y.;Suda, M.;Watanabe, N.;Nakamura, K.;Sugimoto, Y.;Kobayashi, Y.
  24. Chem. Pharm. Bull. v.38 Structure of bisosthenon, a novel dimeric coumarin from Citrus plants Ito, C.;Mizuno, T.;Tanahashim S,;Furukawa, H.;Ju-Ichi, M,;Inoue, M.;Muraguchi, M.;Omura, M;McPhail, D.R.;McPhail, A.T.
  25. Planta Med. v.45 Isolation of drug metabolism modifiers from roots of Angelica Koreana Woo, W.S.;Lee, C.K.;Shim, K.H.
  26. Anal. Sci. Technol. v.2 A study on structure and quantitation of furano-coumarins from Angelica Koreana Max. Kim, T.J.;Lee, S.I.;Yoon, Y.S.;Ko, J.S.
  27. Planta Med. v.61 Inhibitory effects of oriental gerbal medicines on IL-8 induction in lipopolysaccharide-activated rat macrophages Lee, G.I.;Ha, J.Y.;Min, K.R.;Nakagawa, H.;Tsurufji, S.;Chang, I.M.;Kim, Y.
  28. Carcinogenesis v.18 Inhibitory effects of naturally occuring coumarines on the metabolic activation of benzo[a]pyrene and 7,12-dimenthyl benzo[a]abthracene in cultured mouse keratocytes Cai, Y.;Baer-Dubowska, W.;Aswood-Smith, M.;DiGiovanni, J.
  29. 3. Coumarins. J. Nat. Prod. v.51 Plant antimutagenic agents Wall, M.E.;Wani, M.C.;Manikumar, G.;Hyghes, T.J.;Taylor, H.;McGivney, R.;Warner, J.
  30. Chem Pharm. Bull. v.38 Studies on the antitumor=promoting activity of naturally occuring substances. Ⅱ. Inhibition of tumor-promotor-enhanced phospholipid metabolism by umbelliferous materials Okuyama, T.;Takata, M.;Noshino, H.;Nishino, A.;Takayasu, J.;Iwashima, A.
  31. J. Nat. Prod. v.58 Isolation of antifungal and larvicidal constituents of Diplolophium buchanani by centrifugal partition chromatography Marston, A.;Hostettman, K.;Msonthi, J.D
  32. Phytochemistry v.41 Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum Chen, I.S.;Chang, C.T.;Sheen, W.S.;Teng, C.M.;Tsai, I.L.;Duh, C.Y.;Ko, F.N.
  33. Yao Hsueh Pao v.23 The anti-allergic activity of osthol extracted from the fruits of Onidium monnieri(L.) Cussion Chen, Z.C.;Duan, X.B.;Liu, K.R.
  34. Chem. Res. Toxicol. v.6 Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresorufin O-dealkyase by naturally occuring coumarins Cai, Y.;Bennett, D.;Nair, R.V.;Ceska, O.;Ashwood-Smith, M.J.;DiGiovanni, J.
  35. Arch. Pharm. Res. v.17 A cytotoxic component from Angelicae koreanae Radix against L1210 and HL 60 cells Bae, K.W.;Ji, J.M.;Kang, J.S.;Ahn, B.Z.