Isolation and Structure Elucidation of Acyl CoA Synthetase Inhibitor from Bacilus sp. B-6

Bacillus sp. B-6가 생산하는 acyl CoA 합성 효소 억제 물질의 분리 및 구조 결정

Acyl CoA synthetase inhibitor, was purified from the culture broth of a Bacillus sp. B-6, which had been isolated from soil, by chloroform extract, silica gel column chro matography and preparative TLC. The purified acyl CoA synthetase inhibitor showed higher Antifungal activity against C. al-bicans (MIC: 8${\mu}$g/ml). Though the analysis of UV spectrum, melting point, IR spectrum, Mass-spectrum, $^1H$-NMR and $^{13}C$-NMR spectrum, the inhibitor could be identified as phenazine-l-carboxylic acid.