Archives of Pharmacal Research
- Volume 21 Issue 6
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- Pages.729-733
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Topoisomerase I Inhibitors from the Streptomyces sp. Strain KM86-9B Isolated from a Marine Sponge
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Lee, Hong-Kum
(Microbiology Lab., Korea Ocean Research & Development Institute)
;
- Lee, Deuk-Soo (Microbiology Lab., Korea Ocean Research & Development Institute) ;
- Lim, Jung-Hyun (Microbiology Lab., Korea Ocean Research & Development Institute, Department of Horticulure Science, Kon-Kuk University) ;
- Kim, Jung-Sun (College of Pharmacy, Pusan National University) ;
- Im, Kwang-Sik (College of Pharmacy, Pusan National University) ;
-
Jung, Jee H.
(College of Pharmacy, Pusan National University)
- Published : 1998.12.01
Abstract
The crude extract of Streptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. Investigation of the ca usative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids.
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