Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Anticomplementary Activity of Stilbenes from Medicinal Plants

  • Oh, Sei-Ryang (Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology) ;
  • Park, Si-Hyung (Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • Jung, Keun-Young (Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • Lee, Im-Seon (Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • An, Kyung-Seop (Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • Lee, Jung-Joon (Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • Lee, Hyeong-Kyu (Korea Research Institute of Bioscience & Biotechnology, KIST)
  • Published : 1998.12.01
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Abstract

The anticomplementary activity of stilbenes from medicinal plants in Korea was investigated in vitro. 3,5-Dihydroxy-4'-methoxystilbene (3) was most potent with $IC_{50}$ value of $1.5{\times}10^{-4}M$ followed by rhapontigenin (4), oxyresverastrol (2), 2,3,4',5-tetrahydroxystilbene-2-O-beta-glucoside (9), rhaponticin (8), resverastrol (1), and piceid (7). The activity was found to be increased by a methylation on a hydroxy group of C-4' of 1, but decreased by further methylation on hydroxy groups of C-3 and C-5 and glucosylation on any hydroxy group of 1. Addition of hydroxy group on C-2' of 1 or C-3' of 3 was little affected on the anticomplementary activity but the activity was increased by O-glucosylation on C-2 of 1.

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