The Journal of Korean Society of Virology (대한바이러스학회지)

The Korean Society of Virology (대한바이러스학회)
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DNA Methylation in Brain and Liver Tissues of Mice Infected with Scrapie Agent

스크래피에 감염된 마우스의 뇌 및 간조직에서의 DNA Methylation

  • Choi, E.K. (Institute of Environment & Life Science and Department of Microbiology, School of Medicine, Hallym University) ;
  • Uyeno, S. (Department of Radiation Research, Tohoku University School of Medicine) ;
  • Ono, T. (Department of Radiation Research, Tohoku University School of Medicine) ;
  • Carp, R.I. (Department of Virology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island) ;
  • Kim, Y.S. (Institute of Environment & Life Science and Department of Microbiology, School of Medicine, Hallym University)
  • 최은경 (한림대학교 의과대학 미생물학교실 및 환경.생명과학연구소) ;
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  • ;
  • ;
  • 김용선 (한림대학교 의과대학 미생물학교실 및 환경.생명과학연구소)
  • Published : 1998.06.30
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Abstract

DNA methylation degree in the several murine brain and liver genes of different ages and after scrapie infection have been examined by using methylation-sensitive restriction endonuclease digestion. We found that the methylation of c-fos and c-myc in the brain and liver was increased during the late fetal to one month postnatal developmental periods. However, those of the SGP-2, $S100{\beta}$, APP950, PrP, and APLP1 genes were decreased at the same periods. The comparison of the DNA methylation patterns between scrapie infected brains and controls demonstrated there is no significant difference in methylation degree of scrapie-infected brains. These observations indicate that DNA methylation might be importantly related to the aging process. The scrapie-infected murine brain was not significantly developed more senescent than the same age-controls did.

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