The Korean Journal of Pesticide Science (농약과학회지)
- Volume 2 Issue 1
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- Pages.18-23
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- 1998
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- 1226-6183(pISSN)
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- 2287-2051(eISSN)
Synthetic method and insecticidal activity of ricinine
Ricinine의 합성법 및 살충활성
- Kwon, Oh-Kyung (National Institute of Agricultural Science and Technology, RDA) ;
- Lim, Soo-Kil (Department of Agricultural Chemistry, Korea University) ;
- Choi, Dal-Soon (National Institute of Agricultural Science and Technology, RDA) ;
- Kyung, Suk-Hun (Department of Agricultural Chemistry, Kon-Kuk University)
- Published : 1998.04.30
Abstract
In order to obtain leading compound for the development of new pesticide through the organic synthesis of natural products, the synthesis of ricinine, an active compound of Ricinus communis, was established and biological activities of synthetic compounds against insects were examined. The synthetic scheme of ricinine was composed of four steps by the spontaneous condensation of the cyanoacetyl chloride. A modified synthetic process was also estabilshed to enhance the synthetic yield by simple cyclization of ethoxymethylene malononitrile. In the bioassay results of synthetic ricinine and intermediates on four insects, the mortality of ricinine on brown planthopper (BPH, Nilaparvata lugens) and pea weevil(PW, Bruchus rufimanus) was 80% and 75% at the concentration of 1,000
유기합성을 통한 천연물기원 신농약 선도물질을 얻기 위해 피마자잎으로부터 동정된 활성물질 ricinine의 합성방법을 설정한 후 살충활성을 조사하였다. Ricinine은 4단계과정의 cyanoacetic acid 중합반응과 malono nitrile의 단순고리화 반응 2가지 방법으로 합성하였으며 합성 수율은 중합반응보다 단순고리화 반응에서 높은 수율을 나타냈다. 합성된 ricinine및 중간생성물의 살충활성 조사결과 1,000