The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 32 Issue 5
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- Pages.436-442
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- 1998
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- 1225-6714(pISSN)
Acute Myelogenous Leukemia Developed after Radioactive Iodine Therapy and Palliative Radiation Therapy in Metastatic Papillary Thyroid Cancer
갑상선 유두암환자에서 방사성 옥소 치료와 고식적 방사선 치료 후 발생한 급성 골수성 백혈병
- Ko, Tae-Young (Departments of Internal Medicine, Hanil Hospital) ;
- Kwag, Jae-Sik (Departments of Internal Medicine, Hanil Hospital) ;
- Oh, Kyung-Suk (Departments of Internal Medicine, Hanil Hospital) ;
- Lee, Seung-Bai (Departments of Internal Medicine, Hanil Hospital) ;
- Chung, Byung-Sun (Departments of Internal Medicine, Hanil Hospital) ;
- Kim, Eun-Sil (Departments of Nuclear Medicine, Hanil Hospital) ;
- Kim, Chong-Soon (Departments of Internal Medicine, Hanil Hospital)
- 고태영 (한일병원 내과) ;
- 곽재식 (한일병원 내과) ;
- 오경숙 (한일병원 내과) ;
- 이승배 (한일병원 내과) ;
- 정병선 (한일병원 내과) ;
- 김은실 (한일병원 핵의학과) ;
- 김종순 (한일병원 내과)
- Published : 1998.10.30
Abstract
Radioactive iodine treatment has been widely used for nearly 50 years in the treatment of thyroid cancer to ablate residual thyroid tissue after thyroidectomy and to treat metastatic disease. Leukemia is a rare complication associated with the radioactive iodine therapy. The occurrence of leukemia is known to be related to the cumulative dosage of I-131 more than 37 GBq (1 Ci) and also associated with the intervals of less than 12 months between the repeated doses. We report a case of a 52 year-old female patient with papillary cancer of thyroid who developed acute myelogenous leukemia after the total 20.4 GBq (550 mCi) of I-131 therapy over 3.2 years and palliative radiation therapy (3000 cGy) due to multiple bone metastasis of papillary cancer.