대한핵의학회지 (The Korean Journal of Nuclear Medicine)
- 제32권3호
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- Pages.298-304
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- 1998
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- 1225-6714(pISSN)
Re-188이 표지된 황 교질(Sulfur Colloid) 제조와 생체내 분포
Preparation and Biodistribution of Re-188 Sulfur Colloid
- 김영주 (서울대학교 의과대학 핵의학교실) ;
- 정재민 (서울대학교 의과대학 핵의학교실) ;
- 장영수 (서울대학교 의과대학 핵의학교실) ;
- 이용진 (서울대학교 의과대학 핵의학교실) ;
- 이동수 (서울대학교 의과대학 핵의학교실) ;
- 정준기 (서울대학교 의과대학 핵의학교실) ;
- 이명철 (서울대학교 의과대학 핵의학교실) ;
- 송영욱 (서울대학교 의과대학 내과학교실)
- Kim, Young-Ju (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
- Jeong, Jae-Min (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
- Chang, Young-Soo (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
- Lee, Yong-Sin (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
- Lee, Dong-Soo (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
- Chung, June-Key (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
- Lee, Myung-Chul (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
- Song, Yeong-Wook (Department of Internal Medicine, Seoul National University College of Medicine)
- 발행 : 1998.06.30
초록
목적 : Re-188 황 교질을 제조하여 관절염 활액막절제술, 복강내 암전이 치료제로서의 사용 가능성을 알아보았다. 대상 및 방법: Re-188 황 교질의 표지에 EDTA
Purpose: We evaluated the usefulness of Re-188 sulfur colloid for radiation synovectomy and therapy of intraperitoneal metastasis. Materials and Methods: We investigated the labeling efficiency of Re-188 sulfur colloid on various conditions. The stability of Re-188 sulfur colloid was observed at room temperature for 24 h and in human serum and synovial fluid for 72 h. The particle size distribution of Re-188 sulfur colloid was measured by filtering with various pore size filters. Animal experiment was performed in mice and rabbits. Results: The labeling efficiency of Re-188 sulfur colloid was