Anthraquinones and Sterols from the Korean Marine Echiura Urechis unicintus

Chang, Sung-keun;Park, Yong-Hyun;Chai, Seuk;Kim, In-Kyu;Seo, Young-Wan;Cho, Ki-woong;Shin, Jong-Heon;

Journal of the Korean Chemical Society (대한화학회지)

Volume 42 Issue 1
/
Pages.64-68
/
1998
/
1017-2548(pISSN)
/
2234-8530(eISSN)

Korean Chemical Society (대한화학회)

Anthraquinones and Sterols from the Korean Marine Echiura Urechis unicintus

한국산 해양 의충동물 개불에서 Anthraquinone 및 Sterol 성분연구

Chang, Sung-keun (Department of Chemistry, Sunchunhyang University) ;
Park, Yong-Hyun (Department of Food Science & Nutrition, Sunchunhyang University) ;
Chai, Seuk (Department of Chemistry, Sunchunhyang University) ;
Kim, In-Kyu (Department of Chemistry, Sungyunkwan University) ;
Seo, Young-Wan (Korea Ocean Research & Development Institute) ;
Cho, Ki-woong (Korea Ocean Research & Development Institute) ;
Shin, Jong-Heon (Korea Ocean Research & Development Institute)

장성근 (순천향대학교 화학과) ;
박영현 (순천향대학교 식품영양학과) ;
채석 (순천향대학교 화학과) ;
김인규 (성균관대학교 화학과) ;
서영완 (한국해양연구소) ;
조기웅 (한국해양연구소) ;
신종헌 (한국해양연구소)

Published : 19980200

PDF

Download PDF

⟨ Previous Next ⟩

Abstract

Three anthraquinones, chrysophanol, physcion and 1-o-methyl-2-methoxychrysophanol which have $Na^+,K^+-ATPase$ and cyclic AMP phosphodiesterase lowering activities related to cardiotonic action were isolated from the Korean marine echiura, Urechis unicintus. Spectroscopic methods, including HMQC, HMBC and NOE studies, were used to establish the structures.

한국 연해에 서식하고 있는 의충동물 개불(Urechis unicintus)로 부터 강심작용과 관련된 $Na^+,K^+-ATPase$ 저해 작용 및 cyclic AMP phosphodiesterase 저해 작용이 높은 anthraquinones화합물인 chrysophanol, physcion 및 1-o-methyl-2methoxychrysophanol을 분리하였다.주로 HMQC, HMBC 및 NOE 등의 분광학적 방법으로 이들의 구조를 밝혔다.

Keywords

References

Comp. Biochem Physic. v.70B Hall, R. E. (et al.)
Arch Biochem Biophy. v.22B Garey, J. R.(et al.)
Magn. Reson. Chem. v.29 Danielsen, K.;Aksnes, D. W.;Francis, G. W.
Carbon-13 NMR Chemical Shifts in Structures and stereochemical Analysis Pihlaja, K.;Kleinpeter, K.
The Pharmacology of Chinese Herbs Huang, K. C.