Korean Journal of Veterinary Pathology (한국수의병리학회지)

Korean Society of Veterinary Pathology (한국수의병리학회)
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Immunohistochemical study on the p53 and Rb In bladder tumor

방광암에서 p53 Rb 의 면역조직화학적 연구

  • Lee, Kwang-Ju (Dept. of Anatomic Pathology, Chungbuk National University) ;
  • Lee, Myung-Hwan (General Hospital, Taejon Health Sciences Colleage) ;
  • Youn, Nae-Young (Dept. of Obestetrics and Gynecology, Pochon CHA University, Gangnam CHA General Hospital)
  • 이광주 (충북의대해부병리과) ;
  • 이명환 (대전보건대학 이상병리과) ;
  • 윤내영 (포천중문의대 강남차병원 산부인과)
  • Published : 1998.12.01
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Abstract

This study was performed to evaluate whether the loss or overexpression of Rb, and overexpression of p53 were prognostic indicators for bladder neoplasia, 52 tumor specimens from transitional cell carcinoma of the urinary bladder were from 42 male and 10 female patients whose age ranged from 30 to 83 years old(mean age; 63,5 years old), This group included 36 superficial and 16 invasive stage bladder tumors, and grades 16-25, p53 was significantly associated with tumor stage and grade(p＜0,05 in each), but not with tumor recurrence. Loss of Rb gene expression or Rb overexpression was correlated with stage, but not grade. These results suggested that changes of Rb and p53 expression might play an important role in assessing the aggressiveness of human neoplasms.

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