Toxicological Research
- Volume 14 Issue 4
- /
- Pages.501-505
- /
- 1998
- /
- 1976-8257(pISSN)
- /
- 2234-2753(eISSN)
Acute Oral Toxicity of A Novel Combined Antibiotic(Cefatrizine / Clavulanic Acid) in Rats
- Kwon, Jong-Won (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
- Kang, Kyung-Koo (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
- Hyun Cho (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
- Baik, Nam-Gi (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
-
Ahn, Byoung-Ok
(Research Laboratories, Dong-A Pharm. Co. Ltd.)
;
- Kim, Gye-Won (Research Laboratories, Dong-A Pharm. Co. Ltd.) ;
- Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co. Ltd.)
- Published : 1998.12.01
Abstract
The acute toxicity study of combined antibiotic (Cefatrizine / Clavulanic Acid), a formulation consisting of cafatrizine and clavulanic acid in a ratio of 2 : 1, was evaluated in rats. The antibiotic was orally administered with single dose in dose levels up to 5 g/kg (0, 1.25, 2.5, 5 g/kg). Treatment-related effects were limited to soft stool excretion and caecal dilatation, but histologically no morphological changes could be detected in caecum. In hematology, serum-chemistry parameters and histopathology, no drug-related changes were found. The results of the present study indicate that cefatrizine / clavulanic acid has a low toxic potential and the oral