Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Chaetoglobosin A, an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12, 13-Dibutyrate

  • Ko, Hack-Ryong (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Kim , Bo-Yeon (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Ahn , Soon-Cheol (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Oh, Won-Keun (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Kim, Jin-Hee (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Lee, Hyun-Sun (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Kim, Hwan-Mook (Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Han, Sang-Bae (Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Mheen, Tae-Ick (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Ahn, Jong-Seog (Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnolog)
  • Published : 1998.12.01
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Abstract

In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12, 13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the $IC_{50}$ value of 60 pM against bleb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.

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