Journal of Microbiology and Biotechnology
- Volume 8 Issue 5
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- Pages.523-530
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- 1998
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
Rapid and Quantitative Analysis of Clavulanic Acid Production by the Combination of Pyrolysis Mass Spectrometry and Artificial Neural Network
- Kang, Sung-Gyun (Department of Microbiology, College of Natural Sciences, and Research Centre for Molecular Microbiology Seoul National University) ;
- Lee, Dae-Hoon (Department of Microbiology, College of Natural Sciences, and Research Centre for Molecular Microbiology Seoul National University) ;
- Ward, Alan-C. (Department of Microbiology, Medical School, University of Newcastle upon Tyne) ;
- Lee, Kye-Joon (Department of Microbiology, College of Natural Sciences, and Research Centre for Molecular Microbiology Seoul National University)
- Published : 1998.10.01
Abstract
Rapid and quantitative analysis of physiological change and clavulanic acid production was studied by the combination of pyrolysis mass spectrometry (PyMS) and artificial neural network (ANN) in Streptomyces clavuligerus. Firstly, the continuous culture studies were carried out to get the physiological background and PyMS samples. Clavulanic acid production was inversely related to growth rate: Mycelium growth and
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