Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Acarbose Effect for Dexran Synthesis, Acceptor and Disproportionation Reactions of Leuconostoc mesenteroides B-512FMCM Dextransucrase

  • Kim, Do-Man (Department of Biochemical Engineering, Chonnam National University) ;
  • Park, Kwan-Hwa (Research Center for New-Biomaterials in Agriculture, Seoul National University) ;
  • Robyt, John F. (Department of Biochemistry and Biophysics, Lowa State University)
  • Published : 1998.06.01
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Abstract

Acarbose effectively inhibited the synthesis of dextran, and the inhibition pattern was a noncompetitive type with a $K_i$ value of 1.35 mM. It also inhibited the disproportionation reaction of dextransucrase with isomaltotriose and decreased the efficiency of the maltose acceptor reaction. Increased concentration of dextransucrase or maltose in reaction digests, however, decreased the degree of inhibition by acarbose.

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