Journal of Microbiology and Biotechnology
- Volume 8 Issue 3
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- Pages.277-279
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- 1998
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
Hepatoprotective Effect of Extracellular Polymer Produced by Submerged Culture of Ganoderma lucidum WK-003
- Song, Chi-Hyun (Department of Biotechnology, Taegu University) ;
- Yang, Byung-Keun (Department of Biotechnology, Taegu University) ;
- Ra, Kyung-Soo (Department of Food and Nutrition, Technical Junior College) ;
-
Shon, Dong-Hwan
(Medicinal Resources Research Center, Wonkwang University)
;
-
Park, Eun-Jeon
(Medicinal Resources Research Center, Wonkwang University)
;
- Go, Geon-Il (Medicinal Resources Research Center, Wonkwang University) ;
- Kim, Young-Hwoan (Choongwae Pharmaceutical Co.)
- Published : 1998.06.01
Abstract
An extracellular polymer (exo-polymer) with hepatoprotective properties was produced after a 6-day submerged mycelial culture of Ganoderma lucidum WK-003. The glutamic pyruvic transaminase (GPT) activities in the serum of intoxicated Sprague-Dawley rats were decreased from 871 to 263 by the oral administration of the exo-polymer (20 mg/kg/day) for 4 consecutive days. Rhamnose, arabinose, xylose, mannose, galactose, and glucose were found in the exo-polymer along with aspartic acid, glutamic acid, histidine, serine, glycine, arginine, alanine, tryptophan, valine, phenylalanine, isoleucine, and leucine.