Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

A Study on Serum Concentrations of Antioxidant Minerals in Normal Korean Adults

한국 정상성인의 항산화 관련 혈청 무기질 농도에 관한 연구

  • 이양자 (연세대학교 생활과학대학 식품영양과학연구소)
  • Published : 1998.04.01
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Abstract

Studies on relationships between antioxidant nutrients and various chronic diseases are increasing. In this study , serum concentrations of antioxidant minerals(Se, Cu, Zn & Mn) wee measured and compared among normal Korean adults. The ICP -MS method was employed to measure mineral concentrations. The subjects consisted of 329 healthy adults(154 men & 175 women) aged 20-79 years. The mean serum concentration appeared to be 26.4$\pm$0.41 (Se), 89.6$\pm$1.53(Cu), 113.3$\pm$1.56(Zn) & 0.34$\pm$0.05(Mn)$\mu\textrm{g}$/㎗ for men and 24.5$\pm$0.32(Se), 95.1$\pm$1.58(Cu), 133.6$\pm$1.79(Zn) & 0.35$\pm$0.02(Mn) $\mu\textrm{g}$/㎗ for women respectively. Among antioxidant minerals measured, the mean serum levels of Se and Zn were higher in men than in women(p<0.001), whereas that of Cu was higher in women(p<0.01). No significant difference between sex was observed for the mean Mn concentrations. The mean serum levels of Se(p<0.01) and Zn(p<0.05) decreased significantly in the 60's women On the other hand, the Mn concentrations in the 60's of women showed a significant increase(p<0.01). This difference seems to be due to the changes in menopausal status . The Cu levels in men showed a consistent increase with advancing age. The mean Cu/Zn ratios were 0.83 $\pm$0.04 for men and 0.95$\pm$0.02(p<0.01) for women respectively. The fact that this ratio increased significantly at the 60's of men (1.26 ; p<0.001) requires further study in relation to chronic diseases. When analyzed by stepwise multiple regression, drinking positively influenced serum Se and Cu levels for both men and women , smoking, however, negatively influenced all serum mineral levels for women. Further studies are needed to clarify precise roles of antioxidant minerals, their interactions and their relation to disease status.

Keywords

References

  1. Crit. Rev. Food Sci. Nutr. v.35 no.1;2 The role of free radicals and antioxidants : How do we know that they are working? Thomas,M.J.
  2. J. Nutr. v.124 Regulation of fatty acid oxidation in heart Schulz,H.
  3. Crit. Rev. Food Sci. Nutr. v.35 no.1;2 Free radicals and antioxidants in food and in vivo : What they do and how they work Barry,H.;Murica,A.;Chirico,S.;Okezie,I.A.
  4. Am. J. Clin. Nutr. v.53 Antioxidant nutrients and disease prevention : An overview Diplock,A.T.
  5. Kor. J. Lipidology v.3 no.1 Lipid peroxidation and antioxidant nutrition Cho,S.H.
  6. A.Waverly Company(8th ed.) Modern Nutrition in Health and Disease Shils,M.;Olson,J.A.;Shike,M.
  7. FASEB J. v.1 Free radical tissue damage : Protective role of antiocidant nutrients Machlin,L.J.;Bendich,A.
  8. Yonsei University, Ph.D. Thesis Studies on serum concentrations and intake pattern of antioxidant vitamins of the Korean adults and breast cancer patients Kim,M.K.
  9. Kor. J. Nutr. v.30 no.5 Levels and factors affecting serum carotenoids concentrations of adults living in rural area of Korea Ahn,Y.J.;Bak,H.Y.
  10. Kor. J. Nutr. v.27 no.9 Effect of maternal selenium nutrition on pulmonary selenium, glutathione peroxidase, and phophlipid levels in neonatal rats Kim,J.H.
  11. Kor. J. Nutr. v.26 no.3 Effect of dietary selenium of metallothionein synthesis and antioxidative detoxification mechanism in cadmium administered rats glutathione peroxidase, and phophlipid levels in neonatal rats Rhee,S.J.;Jun,S.Y.
  12. Kor. J. Gerontol. v.4 no.1 Effects of dietary selenium on peroxidative damage and antioxidative system in brain of cadimum administered rats Park,M.H.;Rhee,S.J.
  13. Kor. J. Gerontol. v.1 no.2 Effects of dietary selenium on antioxidative detoxication mechnism in liver of lead poisoned rats Rhee,S.J.
  14. Kor. J. Nutr. v.29 no.1 Effect of Vitamin E and selenium on the antioxidative defense system in streptozotocin-induced diabetic rats Rhee,S.J.;Choe,W.K.;Cha,B.K.;Yang,J.A.;Kim,K.Y.
  15. Kor. J. Nutr. v.24 no.6 The study on concentration of serum selenium in patients with hepatoma Shin,W.S.;Hong,S.I.;Jung,M.R.;Kim,J.H.;Na,H.B.
  16. Annal. Chim. Acta. v.289 Elimination of inductively coupled plasma mass spectrometry Gossens,J.;Vanhaecke,F.;Mosens,L.;Dams,R.
  17. Korea Inst. of Food Hygiene Estimated portion sizes of foods for dietary intake survey
  18. Am. J. Clin. Nutr. v.45 Trace elements in human with special reference to selenium Diplock,A.T.
  19. Am. J. Clin. Nutr. v.52 Selenium intake, age, gender and smoking in relation to indices of selenium status of adults residing in a seleniferous area Swanson,C.A.;Longnecker,M.P.;Veillon,C.;Howe,S.M.;Levander,O.A.;Taylor,P.R.;McAdam,P.A.;Brown,C.C.;Stampfer,M.J.;Willett,W.C.
  20. Acta. Pharmacol. Toxicol. v.40 Selenium content of whole blood and serum in adults and children of different ages from defferent parts of Finland Westermark,T.;Raunu,P.;Kirjarinta,M.;Lappalainen,L.
  21. Am. J. Clin. Nutr. v.60 Selenium status, fatty acids, vitamins A and E and agine : The Nove study Olivieri,O.;Stanzial,A.M.;Girelli,D.;Casaril,M.;Trevisan,M.;Guaruni,P.;Terzi,M.;Caffi,S.;Fontana,F.;Casaril,M.;Ferrari,S.;Corrocher,R.
  22. Atherosclerosis v.56 Serum selenium concentration and risk of ischemic heart disease in a prospective cohort study of 3000 males Suadicani,P.;Hein,H.O.;Gyntelberg,F.
  23. Am. J. Clin. Nutr. v.60 Sex affects manganese absorption and retention by humans from a diet adequate in manganese Finley,J.W.;Johnson,P.E.;Johnson,L.K.
  24. Am. J. Clin. Nutr. v.51 Intake, serum concentrations and urinary excretion of manganese by adult males Greger,J.L.;Davis,C.D.;Suttie,J.W.;Lyle,B.J.
  25. Am. J. Clin. Nutr. v.55 Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron statua in women Davis,S.D.;Greger,J.L.
  26. Nutr. Rev. v.10 Effects of sex and age on manganese metabolism Lee,D.;Korynta,E.;Johnson,P.
  27. Trace Element Metabolism in Animals(2nd ed.) Changes in circulating copper, manganese and zinc with the onset of lay on the pullet Hill,R.;Hoekstra,W.G.(ed.);Suttie,J.W.(ed.);Ganther,H.E.(ed.);Mertz,W.(ed.)
  28. Am. J. Clin. Nutr. v.51 Zinc, magnesium, copper and protein concentrations in human saliva : Age-and-sex- ralated differences Bales,C.W.;Freeland-Graves,J.H.;Askey,S.;Behmardi,F.;Pobocik,R.S.;Fickel,J.J.;Greenlee,P.
  29. Kor. J. Inter. Med. v.33 The study of concentrations of serum copper and zinc in liver chirrhosis and liver cancer patients Ahn,K.Y.;Kim,M.J.;Kim,W.H.;Cho,S.Y.;Kim,M.W.;Cho,K.K.
  30. Kor. J. Nutr. v.24 no.6 The study on concentration of serum copper and zinc in stomach cancer patients Chung,Y.D.;Hong,S.I.;Na,H.B.;Shim,Y.H.
  31. Adv. Exp. Med. Biol. v.258 Effect of Estrogen on serum and tissue levels of copper and zinc Mahta,S.W.;Eikum,R.
  32. Gynecol. Obstet. Invest. v.25 Trace Elements during 2 years' oral contraception with low-estrogen preparations Liukko,P.;Erkkola,P.;Pakarinen,P.;Janstrom,S.;Nanto,V.;Gronroos,M.
  33. Am. J. Clin. Nutr. v.56 Serum copper and zinc in random samples of the population of Nothern Ireland McMaster,D.;McCrum,E.;Patterson,C.C.;Kerr,M.M.;O'Reilly,D.O.;Evans,A.E.;Love,A.H.G.
  34. Nutr. Res. v.9 Sex and age changes on serum zinc levels Rea,I.M.
  35. Am. J. Clin. Nutr. v.55 Factors ralated to the plasma fatty acid profile in healthy subjects with special reference to antioxidant micronutrient status : A multivariate analysis Cabre,E.;Perigo,J.L.;Mingorance,M.D.;Banares,F.F.;Abad,A.;Esteve,M.;Gil,A.;Lachia,M.;Huix,F.G.;Gassull,M.A.
  36. J. Nutr. v.111 Plasma lecithin : Cholestrol acyltransferase in copper-deficient rats Lau,B.W.C.;Klevay,L.M.
  37. J. Nutr. v.124 Pool size and concentration of plasma cholesterol are increased and tissue copper levels are reduced during early stages of copper deficiency in rats AL-othman,A.A.;Rosenstein,F.;Lei,K.Y.
  38. Circulation v.64 Magnesium and trace metals : Risk factors for coronary heart disease? Manthey,J.;Stoeppler,M.;Morgensten,W.
  39. Am. J. Epidemiol. v.122 Trace metals and coronary heart disease risk indicators in 152 elderly men(the Zutphen study) Kromhout,D.;Wibowo,A.A.E.;Herber,R.F.M.
  40. Adv. Exp. Med. Biol. v.258 Copper and zinc status in moderate alcohol intake Frimpong,N.A.;Louis-Charles,J.
  41. Am. J. Clin. Nutr. v.50 Moderate alcohol intake and nutritional status in nonalcoholic elderly subjects Jaques,P.F.;Sulsky,S.;Hartz,S.C.;Russell,R.M.