Effect of Glycyrrhizin on the Aoptosis of Melanoma Cells in Mel/ret Transgenic Mice

Glycyrrhizin이 Mel/ret transgenic mice에서의 melanoma 세포의 apoptosis에 미치는 영향

  • 오찬호 (우석대학교 환경 및 생명공학부) ;
  • 염정열 (우석대학교 약학과)
  • Published : 1998.12.01

Abstract

The effect of glycyrrhizin on melanoma cells was investigated. DNA fragmentation in cultured melanoma cells was promoted by the addition of glycyrrhizin in a dose dependent manner. Administration(i.m.) of glycyrrhizin to Mel/ret transgenic mice resulted in apoptosis induction, reduction of mitochondrial transmembrane potential in melanoma cells. Decreased B220+ B cells were recovered by the treatment of glycyrrhizin in splenocytes and mesenteric lymph node cells, while Thy-1+ T cells were not influenced. Results suggested that glycyrrhizin acted as an inducer of apoptosis of melanoma cells and an immuno-potentiator via recovered B lymphocyte population in Mel/ret transgenic mice.

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