KSBB Journal
- Volume 13 Issue 4
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- Pages.456-460
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- 1998
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- 1225-7117(pISSN)
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- 2288-8268(eISSN)
Production of an Anticoagulant Hirudin by Fed-batch and Continuous Cell Recycle Fermentations Using Recombinant Saccharomyces cerevisiae
유가식과 세포재순환 연속공정을 이용한 항혈전제 hirudin의 생산
Abstract
Fed-batch fermentations were carried out in order to improve the efficiency of hirudin production by recombinant Saccharomyces cerevisiae. A fed-batch fermentation done with the optimized semi-synthetic medium resulted in a maximum hirudin concentration of 342mg/