Biotechnology and Bioprocess Engineering:BBE

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Elicitation of Camptothecin Production in Cell Cultures of Camptotheca acuminata

  • Song, Seung-Hoon (Department of Chemical Engineering, Seoul National University) ;
  • Byun, Sang-Yo (School of Chemical Engineering and Biotechnology, Ajou University, Suwon, Kyungki-do)
  • Published : 1998.12.01
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Abstract

Camptothecin productoin was increased with elicitors, methyl jasmonate, jasmonic acid, yeast extract elicitor, and ferulic acid in suspension cultures of Camptotheca acuminata. Jasmonic acid was found to be the most efficient elicitor. Camptothecin production increased 11 times by using the optimum dosing concentration of jasmonic acid which was 50 ${\mu}$M. The kinetics of camptothecin accumulation in response to the treatment with jasmocin acid showed that the comptothecin accumulation reached the maximum value at 4 days after jasmonic acid dosing and then a rapid decrease in camptothecin accumulation was observed.

Keywords

References

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