Archives of Pharmacal Research
- Volume 21 Issue 4
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- Pages.481-484
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Yomogin, an Inhibitor of Nitric Oxide Production in LPS-Activated Macrophages
- Ryu, Jae-Ha (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Sookmyung Womens University) ;
- Lee, Hwa-Jin (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Sookmyung Womens University) ;
- Jeong, Yeon-Su (College of Pharmacy. Sookmyung Womens University) ;
-
Ryu, Shi-Yong
(Korea Research Institute of Chemical Technology)
;
- Han, Yong-Nam (Natural Products Research Institute, Seoul National University)
- Published : 1998.08.01
Abstract
In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plant Artemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.
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