Archives of Pharmacal Research
- Volume 21 Issue 4
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- Pages.363-369
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Differential Effects of Nongenotoxic and Genotoxic Carcinogens on the Preneoplastic Lesions in the gat Liver
- Kim, Dae-Joong (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administration) ;
- Lee, Kook-Kyung (Department of Pathology, National Institute of Toxicology Research, Korea Food and Drug Administration) ;
- Hong, Jin-Tae (Department of Toxicology, National Institute of Toxicology Research, Korea Food and Drug Administration)
- Published : 1998.08.01
Abstract
Glutathione S-transferase placental form (GST-P) positive foci development and its expression in liver exposed by nongenotoxic carcinogens phenobarbital (PB) and clofibrate (CF), and genotoxic carcinogen 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) were investigated as a measure of carcinogenic potential of these chemicals. Male F344 rats were initially given a single intraperitioneal injection of diethyinitrosamine (200 mg/kg), and 2 weeks later, animals were fed diets containing 0.03% IQ or 0.5% CF or 0.05% PB or basal diet as a control for 6 weeks. All rats were subjected to two-thirds partial hepatectomy (PH) at week 3. Sequential sacrifice of rats was performed at 8 weeks or 52 weeks, and liver tissues were examined for immunohistochemical staining of GST-P positive foci. The numbers (No./
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