Archives of Pharmacal Research
- Volume 21 Issue 3
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- Pages.330-337
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- 1998
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Reactivity and Suitability of t-Boc-protected Thiophosphotyrosine Intermediate Analogs for the Solid or Solution Phase Peptide Synthesis
- Kim, Eun-Kyung (College of Pharmacy, Yeungnam University) ;
- Choi, Hee-Sung (Dong Kook Pharm Co., Central Research Institute) ;
- Lee, Eung-Seok (College of Pharmacy, Yeungnam University)
- Published : 1998.06.01
Abstract
N-(tert-Butoxycarbonyl)-O-(dimethythiophosphono)-L-tyrosine (6) and N-(tert-butoxycarbonyl)-O-(dicyanoethylthiophosphono)-L-tyrosine (15) were prepared as intermediates for the synthesis of thiophosphotyrosine-containing peptides. The reactivity and suitability of two compounds for the solid phase or solution phase peptide synthesis utilizing t-Boc chemistry were examined.
Keywords
- Thiophosphotyrosine;
- Phosphotyrosine;
- Protein tyrosine kinase(PTK);
- Peptide synthesis;
- Cyanoethyl protection