Biological Activity of Acidic Polysaccharide of Korean Red Ginseng 1.-Effects on Alcohol Detoxification System in the Llver of Alcohol-intoxicated Rats

홍삼 산성다당체의 생리활성 연구(I)-알코올 중독 동물의 간장 알코을 해독계에 미치는 영향

The effects of acidic polysaccharide of Korean red ginseng (AcPS) on metabolisms of drug and alcohol in the liver were investigated. We could find that treatment of AcPS to six-week ethanol administered rats lowered the levels of alcohol and acetaldehyde in serum. We also we found that treatment of AcPS normalized the elevated activities of free radical generation system, decreased activities of detoxification system such as ${\gamma}$-glutamylcysteine synthetase and glutathione S-transferase, and decreased activities of acetaldehyde metabolizing system. The cytosolic alcohol dehy drogenase and microsomal ethanol oxidizing system (MEOS) were strongly enhanced.