Radiation Oncology Journal
- Volume 16 Issue 3
- /
- Pages.311-323
- /
- 1998
- /
- 2234-1900(pISSN)
- /
- 2234-3156(eISSN)
Concurrent Chemoradiotherapy in Locally Advanced Carcinoma of The Uterine Cervix : A Phase I/II Prospective Study
국소적으로 진행된 자궁경부암의 방사선치료와 복합 항암화학요법의 동시치료 결과
- Kang One Chul (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Choi Eun Kyung (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Chung Weon Kuu (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Kim Jong Hoon (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Chang Hyesook (Departments of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Kim Yong Man (Departments of Obstetrics and Gynecology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Kim Young Tak (Departments of Obstetrics and Gynecology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Nam Joo Hyun (Departments of Obstetrics and Gynecology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Mok Jung-Eun (Departments of Obstetrics and Gynecology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Lee Moo-Song (Departments of Preventive Medicine, Asan Medical Center, College of Medicine, University of Ulsan)
- 강원철 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
- 최은경 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
- 정원규 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
- 김종훈 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
- 장혜숙 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
- 김용만 (울산대학교 의과대학 서울중앙병원 산부인과) ;
- 김영탁 (울산대학교 의과대학 서울중앙병원 산부인과) ;
- 남주현 (울산대학교 의과대학 서울중앙병원 산부인과) ;
- 목정은 (울산대학교 의과대학 서울중앙병원 산부인과) ;
- 이무송 (울산대학교 의과대학 서울중앙병원 예방의학과)
- Published : 1998.09.01
Abstract
Purpose : Prospective, single arm, Phase I/II clinical trial was performed to assess the efficacy and toxicity of the concurrent chemotherapy and definitive radiotherapy (RT) in patients with previously untreated locally advanced carcinoma of the uterine cervix. Methods and Materials : From Mar 1992 to January 1997, a total of 73 patients with advanced cervical carcinoma were entered on the protocol but 5 patients were excluded in analysis because of patients' refusal of treatment. Their ages ranged from 31 to 77 years, median 58 years. The International Federation of Gynecology and Obstetrics (FIGO) stage distribution was as follows: IIB 46, IIIA 2, IIIB 15 and IVA 5. RT consisted of external beam irradiation to 4,140-5,040 cGy/23-28 fractions plus high dose rate intracavitary treatments to deliver a dose of 30-35 Gy to point A in 6-7 fractions. During the intracavitary treatments parametrial boost was delivered for point B dose of 60 Gy in stage IIB and 65 Gy in stage IIIB. Two cycles of concurrent 5-fluorouracil and cisplatin (FP) chemotherapy (5-fluorouracil 1,000 mg/
목적 : 국소적으로 진행된 자궁경부암환자에서 방사선 치료와 5-FU, CDDP 복합항암요법의 동시 치료에 의한 종양관해율, 치료부작용, 예후인자, 실패양상과 생존율을 분석하기 위하여 전향적 제 2상연구를 시행하였다. 대상 및 방법 : 울산대학교 서울중앙병원 방사선종양학과와 산부인과에서 1992년 5월부터 1997년 1월까지 FIGO병기 IIB, III, IVA의 국소적으로 진행된 자궁경부암으로 진단받고 치료한 환자 73명중 방사선치료와 동시에 2회의 FP 항암요법을 시행한 68명을 대상으로 분석을 시행하였다. FIGO병기에 의한 분포는 IIB 46명, IIIA 2명, IIIB 15명, IVA 5명이었고, 이들의 연령분포는 31세에서 77세까지로 중앙값 58세이었다. 방사선치료시 외부조사는 전골반부에 4,140-5,040 cGy를 시행후 192Ir 고선량 근접치료기로 주 3회씩 6-7회의 강내조사를 시행하며 동시에 B점추가 조사를 시행하여 A점에 7,500-8,000 cGy, B점에 6,000-6,500 cGy가 되도록 조사하였다. FP(5-FU; 1,000mg/