Radiation Oncology Journal
- 제16권2호
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- Pages.115-123
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- 1998
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
전골반 방사선 분할 조사시 방사선량에 따른 염색체이상 빈도의 변화 양상
Chromosomal Aberration in Fractionated Radiotherapy
- Yun, Hyong-Geun (Department of Therapeutic Radiology, Dankook University College of Medicine) ;
- Ha, Sung-Sung (Department of Therapeutic Radiology, Seoul National University College of Medicine)
- 발행 : 1998.06.01
초록
자궁 경부암으로 전 골반에 균일하게 방사선 치료를 받은 3명의 환자들을 대상으로 말초혈액임파구의 염색체이상 빈도를 정기적으로 측정함으로써 반복 피폭에 의한 염색체이상 빈도의 변화양상을 구명하고자 하였다. 방사선 조사전에 채취한 혈액에서 얻은 Ydr 값은 0.0060, 0.0000, 0.0029였다. 방사선량이 증가함에 따라 Ydr 값은 직선적으로 증가하였고 측정치들로부터 구한 선형 회귀식은
Purpose : This study was tried to evaluate the effect of the partial body fractionated irradiation on the frequency of chromosomal aberration. Materials and Methods : In three patients with uterine cervix carcinoma, chromosomal aberrations were analyzed during fractionated external beam radiotherapy Radiation field included whole pelvis and total dose was 5040 cGy in 28 fractions. Results : The values of the frequency of dicentrics and rings (Ydr) in pre-irradiated peripheral lymphocytes in three patients were 0.0060, 0.0000, and 0.0029, respectively. The frequency of dicentrics and rings, estimated during the course of radiotherapy, increased with radiation dose and best fitted to the linear equation,