대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

치매에 관한 최근의 연구 동향

The latest development in Dementia

  • 나창수 (동신대학교 한의과대학 내과학교실) ;
  • 김정상 (동신대학교 한의과대학 내과학교실) ;
  • 채우석 (동신대학교 한의과대학 내과학교실) ;
  • 박석천 (동신대학교 한의과대학 내과학교실)
  • 발행 : 1998.08.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Dementia is the neurodegenerative process that affects cognition, behavior and function and one of the most prominent diseases of dementia is Alzheimer's disease(AD). AD is a dementing illness characterized clinically by the progressive and irreversible deafferentation of the limbic system, association neocortex and basal forebrain. A number of conditions are known to be predisposing risk factors for AD. In several of these, initiation of glial-mediated inflammatory pathways as a mechanism of AD is getting a lot of attention. On the other hand, a biochemical marker for monitoring the onset and progression of the disease would be a valuable tool for disease management. Also such a marker might be used as an end point in clinical intervention protocols. This biochemical marker will have the potential for identifying subjects afflicted with the disease and possibly for monitoring the onset and longitudinal progression of the disease. Here we have reviewed the latest papers of different approaches to AD. Of course, there is a section of PET which is very useful clinically nowadays.

키워드

참고문헌

  1. J. Neuropathol. Exp. Neurol. v.48 A4 protein in Alzheimer's disease: primary and secondary cellular events in extracelluarl amyloid deposition Rozemuller, J.M.;Eikelenboon, P.;Stam, F.C.;Beyreuther, K.;Masters, C.L.
  2. Proc. Natl. Acad. Sci. USA v.86 Brain interleukin 1 and S-100 immunreactivity are elevated in Down syndrome and Alzheimer disease Griffin, W.S.T.;Stanley, L.C.;Ling, C.;White, L.;Macleod, V.;Perrot, L.J.;White, C.L.III.;Araoz, C.
  3. Neurosci. Lett. v.119 Acute phase proteins are present in amorphous plaques in the cerebral but not cerebeller cortex of patients with Alzheimer's disease Rozemuller, J.M.;Stam, F.C.;Eikelenboom, P.
  4. J. Neuropathol. Exp. Neurol. v.54 Interleukin-1 expression in different plaque types in Alzheimer's disease Griffin, W.S.T.;Sheng, J.G.;Roberts, G.W.;Mrak, R.E.
  5. J. Neuropathol. Exp. Neurol. v.55 Correlation of astrocytic S100${\beta}$ expression with dystrophic neurities in amyloid plaques of Alzheimer's disease Mrak, R.E.;Sheng, J.G.;Griffin, W.S.T.
  6. Eur. J. Immunol. v.19 Monokine production by microglial cell clones Righi, M.;Mori, L.;De Libero, G.;Sironi, M.;Biondi, A.;Mantovani, A.;Donini, S.D.;Ricciardi-Castagonoli, P.
  7. Addiction Biology v.1 Are tobacco and alcohol use related to Alzheimer's disease? a critical assessment of the evidence and its implications Tyas, S.L.
  8. Science v.228 Interleukin-1 stimulation of astroglial proliferation after brain injury Giulian, D.;Lachman, L.B.
  9. Brain Res. Rev. v.17 Brain macrophages: evaluation of microglia and their functions Thomas, W.E.
  10. Proc. Natl. Acad. Sci. USA v.86 Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells Goldgaber, D.;Harris, H.W.;Hla, T.;Maciag, T.;Donnelly, R.G.;Jacobsen, J.S.;Vitek, M.P.;Gajdusek, D.C.
  11. Brain Res. Mol. Brain Res. v.16 Expression of amyloid precursor protein mRNAs in dndothelial, neuronal and glial cells: modulation by interleukin-1 Forloni, G.;Demicheli, F.;Giorgi, S.;Bendotti, C.;Angeretti, N.
  12. Cell. Mol. Neurobiol. v.10 Interleukin-1 stimulates the beta-amyloid precursor protein promotor Donnelly, R.J.;Freidhoff, A.J.;Beer, B.;Blume, A.J.;Vitek, M.P.
  13. Proc. Natl. Acad. Sci. USA v.89 Cholinergic agonists and interleukin-1 regulate processing and secretion of the Alzheimer/A4 amyloid protein precursor Buxbaum, J.D.;Oishi, M.;Chen, H.I.;Pinkas-Kramarski, R.;Jaffe, E.A.;Gandy, S.E.;Greengard, P.
  14. J. Neurosci. Res. v.33 Growth control of cultured microglia Ganter, S.;Northoff, H.;Mannel, D.;Gebicke-Harter, P.J.
  15. J. Immunol. v.150 In vitro production of IL-6, IL-1 beta, and tumor necrosis factoralpha by human embryonic microglial and neural cills Sebire, G.;Emilie, D.;Wallon, C.;Hery, C.;Devergne, O.;Delfraissy, J.F.;Galanaud, P.;Tardieu, M.
  16. J. Immunol. v.150 Cytokine production by human fetal microglia and astrocytes . Differential induction by lipopolusaccharide and IL-1 beta Lee, S.C.;Leu, W.;Dickson, D.W.;Brosnan, C.F.;Berman, J.W.
  17. J. Neurosci. v.8 Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization Giulian, D.;Woodward, J.;Youmg, D.G.;Krebs, J.F.;Lachman, L.B.
  18. Peeripheral Signaling of the Brain. Role in Neural Immune Interactions, Learning and Memory Interleukin-1 in the central nervous system: a role in the acute phase response and in brain injury, brain development and the pathogenesis of Alzheimer's disease Berkenbosch, F.;Robakin, N.;Blum, M.;Frederickson, R.C.A.(ed.);McGaugh, J.L.(ed.);Felten, D.L.(ed.)
  19. Neurobiol. Aging In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis Sheng, J.G.;Ito, K.;Skinner, R.D.;Mrak, R.E.;Rovnaghi, C.R.;Van Eldik, L.J.;Griffin, W.S.T.
  20. J. Clin. Immunol. v.9 Astrocytes and intracerebral immune responses Frohman, E.M.;van den Noort, S.;Gupta, S.
  21. J. Clin. Invest. v.78 Cachetin/tumor necrosis factor regulates hepatic acute-phase gene expression Perlmutter, D.H.;Dinarello, C.A.;Punsal, P.I.;Colten, H.R.
  22. Neurobiol. Aging v.15 Expression of the Alzheimer amyloid-promoting factors ${\alpha}_1$-antic-hymmotrypsin and apolipoprotein E is induced in astrocytes by IL-1 Das, S.;Geller, L.;Niethammer, M.;Potter, H.
  23. Neuropathol. Appl. Neurobiol. v.22 Apolipoprotein E distribution among different plaque types in Alzheimer's disease : implications for its role in plaque progression Sheng, J.G.;Mrak, R.E.;Griffin, W.S.T.
  24. Neurobiol. Aging v.15 Apolipoprotein E-immunoreactivity in aged Rhesus monkey cortex: Colocalization with amyloid plaques Mufson, E.J.;Benzing, W.C.;Cole, G.M.(et al.)
  25. J. Neurosci. Res. v.39 S100${\beta}$ protein expression in Alzheimer's disease: potential role in the pathogenesis of neuritic plaques Sheng, J.G.;Mrak, R.E.;Griffin, W.S.T.
  26. Prog. Brain Res. v.86 S100${\beta}$ as a neurotrophic factor Marshak, D.R.
  27. J. Biol. Chem. v.267 S100${\beta}$ stimulates calcium fluxes in glial and neuronal cills Barger, S.W.;Van Eldik, L.J.
  28. Nature Medicine v.2 Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease Kennard, M.;Feldman, H.;Yamada, T.;Jefferies, W.A.
  29. Brain Res. v.712 Coincident expression and distribution of melano-transferrin and transferrin receptor in human brain capillary endothelium Rothenberger, S.(et al.)
  30. Brain Res. v.712 Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease express melanotransferrin Jefferies, W.A.(et al.)
  31. J. Epidemiol. Community Health v.50 Further thoughts on the aluminum-Alzheimer's disease link Forbes, W.F.;McLachlan, D.R.C.
  32. Science v.268 Zinc and Alzheimer's disease Bush, A.I.(et al.)
  33. Clinical. Chemistry v.43 Telomeres and telomerase: biological and clinical importance Dahse, R.;Fiedler, W.;Ernst, C.
  34. Mutat. Res. v.236 In vivo loss of telomeric prpeats with age in humans Lindsay, J.;McGill, N.;Lindsay, L.;Green, D.;Cooke, K.
  35. J. R. Sac. Med. v.87 Hutchinson-Gilford syndrome Stables, G.;Merley, W.
  36. Science v.272 Premature aging gene discovered Benniel, E.
  37. 핵의학 고창순(編著)
  38. 중앙의학 v.52 no.4 양전자방출단층촬영의 최근 동향 이명철;고창순
  39. Neurology v.47 Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging Meltzer, C.C.;Zubieta, J.K.;Brandt, J.;Tune, L.E.;Mayberg, H.S.;Frost, J.J.
  40. Neurology v.47 Cortical and subcortical chemical pathology in Alzheimer's disease as assessed by multislice proton magnetic resonance spectroscopic imaging Tedeschi, G.;Bertolino, A.;Lundbom, N.;Bonavita, S.;Patronas, N.J.;Duyn, J.H.;Metman, V.;Chase, T.N.;Di Chiro, G.
  41. Neurology v.36 Positron emission tomography in Alzheimer's disease Dura, R.;Grady, C.;Haxby, J.(et al.)
  42. Positron emission tomography and autoradiography : Principles and applications forthe brain and heart Phelps, M.E.;Mazziotta, J.C.;Schelbert, H.R.(et al.)
  43. Neuroradiol v.30 Positron tomography in ischemic cerebrovascular disease Frackowiak, R.J.S.
  44. J Cereb Blood Flow Metab v.7 The effect of disease sevrity on local cerebral glucose metabolism in Alzheimer's disease Jameson, D.G;Chawluk, J.B.; Alavi, A.(et al.)