The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Studies on the Antiallergic Action of Gegangjochohwangsinbutang

계강조초황신부탕(桂薑棗草黃辛附湯)의 항(抗)알레르기 작용(作用)에 대한 연구(硏究)

  • Baek, Gyong-Lyong (Dept. of Oriental Rehabilitation Medicine, Won-kwang Univ.) ;
  • Kwon, Young-Dal (Dept. of Oriental Rehabilitation Medicine, Won-kwang Univ.) ;
  • Park, Kwan-Ha (Dept. of Fish Pathology, college of Ocean Science of Technology, Kunsan National Univ.) ;
  • Ryu, Do-Gon (Dept. of Physiology, college of oriental medicine, Won-kwang Univ.) ;
  • Song, Yong-Sun (Dept. of Oriental Rehabilitation Medicine, Won-kwang Univ.)
  • 백경룡 (원광대학교 한의과대학) ;
  • 권영달 (원광대학교 한의과대학) ;
  • 박관하 (군산대학교 해양과학대학) ;
  • 류도곤 (원광대학교 한의과대학 생리학 교실) ;
  • 송용선 (원광대학교 한의과대학)
  • Published : 1998.10.30
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Abstract

Antiallergic action and the effect on normal immune function of an oriental medical prescription Gegangjochohwangsinbutang (GJHB) water extract were examined in several experimental models. GJHB water extract at 600-1,800 mg/kg/day administered orally for one week significantly recuded the passive cutaneous anaphylaxis in rats in a dose-dependent manner. Whereas the extravasation induced by intradermal leukotriene D4 in rats was significantly inhibited by GJHB water extract at 600-1,800 mg/kg/day, po, for one week, but that by histamine or serotonin was not influenced. In a rat asthma model, the delayed airway resistance in ovalbumin-induced asthmatic response was significantly attenuated by GJHB water extract of 1,800 mg/kg/day, po, administered for one week. It was also found that GJHB water extract at 1 mg/kg concentration in vitro relaxed the isolated uinea pig trachea contracted by leukotrien D4, but not that by histamine. The above findings indicate that GJHB water extract can ameliorate the adverse effect of type Ⅰ allergy such as asthma. This pharmacological action seems to derive from an inhibition of GJHB water extract on leukotriene D4-related physiological change.

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References

  1. 原色最新醫療大百科事典 v.2 新太陽社 編輯局 百科事典部
  2. 肝系內科學 全國韓醫科大學肝系內科學敎授
  3. 最新免疫學 李淵台
  4. 綜合微生物學 微生物學分科會
  5. Comp. Ther v.11 Therapy for allergic rhinitis. Crawford L.V.;Cohen R.
  6. Clinical aspect of immunology Classification of allergic reactions responsible for clinical hypersensitivity and disease Cooms RRA;Gell PGH(eds.)
  7. Allergy: Princeples and practice. Anaphylaxis. Wasserman SI.;Middleton E, Jr;Reed CE;Ellis EF(eds.)
  8. 월간 임상약학사 v.7 no.1 月刊臨床藥學 鞠泓一
  9. 內科學 李文鎬(外)
  10. HARRISON'S 내과학 Kurt J. Isselbacher
  11. J. Otolaryngol. v.12 A computer tomographic study of nasal mucosa: effects of vasoactive substances. Cole P.;Haight J.S.J.;Cooper P.W.;Kassel E.E.
  12. 正統金櫃要略 中國中醫硏究院
  13. 傷寒論釋詮 蔡仁植
  14. 診療와 優秀處方 柳基遠
  15. 臨床應用 새韓方處方解設 矢數道明
  16. 大韓外官科學會誌 v.10 no.1 桂枝湯 加味方의 알레르기 鼻炎에 對한 治驗報告 金璟濬(外)
  17. 醫林 v.27 no.210 李文瑞
  18. 醫林 v.19 no.63 方晃秀
  19. 醫林 v.20 no.166 徐文敎
  20. Histamine and anti-histaminics. RelationshiP between histamine and the autonomous nervous system. Von Eu1er US.;Rocha e Silva M(eds.)
  21. Gen. Pharmacol. v.22 Rat heart anaphylaxis: Influence of mediator antagonists. Bakathir HA;Gissler J;Hirschelmann R.
  22. Int. Arch. Appl. Immunol. v.92 A method for evaluating arlti-allergy drugs by simultaneously induced passive cut-aneous anaphylaxis and mediator reac-tions. Koda A;Miura T;Inagki N;Sakamoto O;Arimura A;Nagai H;Mori H.
  23. 韓方治療製의 標準化 規格 統一 硏究 李尙仁(外)
  24. Microbiol. Immunol. v.22 A new method for extraction of extrav-asated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guinea Pigs and rats. Katayama S;Shionoya H;Ohlake S
  25. J. Pharmacol. Exp. Ther. v.127 A method for the fluorometric assay of histamin Shore PA;Burkhalter A;Cohen VH, Jr.
  26. Naunyn Schmiedebergs Arch. Exp, Pathol. Pharmacol. v.195 Versuchsanor-dnung zu Untersuchungenan der Bronchia-lmuskulatur． Konzett H.;Rossler R.
  27. 大韓韓醫學會誌 v.11 no.2 免疫疾患의 韓方槪念과 治療에 關한 文獻的 考察 蔡禹錫
  28. 韓方臨床 알레르기 康秉秀
  29. 醫宗金鑑 (上冊) 吳謙(外)
  30. 原色臨床本草學 辛民敎
  31. 校正方劑大辭典 江克明;包明蕙
  32. 本草求眞 黃宮
  33. 中草藥學 上海中醫學院
  34. 新編中藥大辭典 新文豊出版公司
  35. 실용동의약학 科學百科辭典出版社
  36. 傷寒論辨證表解 杜雨茂
  37. 傷寒論湯證新編 郭予光(外)
  38. 傷寒論槪論 朴憲在
  39. 傷寒論重編 楊宏仁
  40. Int. Arch. Allergy. Immunol. v.103 Pharamcological evaluation of the inhibitory effect of extracts from Anchietia salutaris on the histamine release induced in the rat the guinea Pig. Gomes JC;Di Stasi LC;Saarbosa F;Barata LES
  41. Jpn. J. Pharmacol. v.45 Strain difference in an allergic asthma model in rats. Misawa M;Takenuchi K;Abiru T
  42. Chem. Br. v.21 Antiasthmatic agents: the discovery of intel. Suschitzki JL
  43. J. Cell. Biol. v.1211 Exocytosis in mast cells by2 basic secretagogues: evidence for direct activa-tionof GTP-binding proteins. Aridor M;Traub LM;Sagi-Eisenberg R
  44. Phar-macol. Rev. v.40 Inflammatory mediators and asthma. Barnes PJ;Chung KF;Page CP
  45. Int. Arch. Allergy Appl. Immunol. v.94 Allergic onflammation and its pharma-cological modulation in asthma. Holgate ST;Djukanovic R;Wilson J;Roche W;Britten K;Howarth PH
  46. Ann. Rev. Phamacol. Toxicol. v.23 Agents that release histamine form mast cells. Lagunoff D;Martin TW;Read G
  47. J. Biol. Chem. v.262 Theac-tion of Ca++ ionophores on rat basophilic(2H3) cells are dependent on cellular ATP and hydrolysis of inositol Phospholipids: a comparison with antigen stimulation. Lo TN;Saul W;Beaven MA
  48. Eur. J. Pharmacol. v.143 no.1 Garceau D;Ford-Hutchisno AW;Charleson S