Antioxidant Effects of GaMiHyangSaYukGunJaTang against Gastric Mucosal Lesions induced by Indomethacin

가미향사육군자탕(加味香砂六君子湯)의 Indomethacin 유도 위점막손상 에 미치는 항산화효과(抗酸化效果)

  • 김경선 (동국대학교 한의과대학 생리학교실) ;
  • 신흥묵 (동국대학교 한의과대학 생리학교실)
  • Published : 1998.04.30

Abstract

This study was carried out to investigate the protective effects of GaMiHyangSaYukGunJaTang on gastric mucosal lesions caused by indomethacin in rats.The test group was injected with indomethacin after the oral administration of GaMiHyangSaYukGunJaTang, while the control group was injected only with indomethacin. The lipid peroxidation level increased considerably in the control group, but superoxide disnurtase(SOD), catalase and glutathione(GSH) levels remarkably decreased. The following effects induced by indomethacin were observed in the stomach of the control group; mucosa hemoIThagic infarct, mucosa cell necrosis, leukocyte appearance, mucosa hemorrhagic erosion and gastric pit disawearance. In the test group, lipid peroxides level was significantly reduced compared with the control group While SOD, catalase and GSH levels considerably increased. The following effects were also observed in the stomach of the test group; mucosa hemorrhagic infarct, mucosa cell necrosis, leukocyte appearance and mucosa hemorrhagic erosion occured far less and gastric pit disappearance was not observed at all. This results suggest that GaMiHyangSaYukGunJaTang is effective in the remedy of gastric mucosal lesions as GaMiHyangSaYukGunJaTang suppresses the production of the lipid peroxides and free radicals induced by indomethacin and activates SOD, catalase and GSH.

Keywords

References

  1. 臟腑辨證論治 金完熙;崔達永
  2. 東醫寶鑑 許浚
  3. 方藥合編 黃道淵
  4. 歸脾湯이 흰쥐의 胃潰瘍에 미치는 影響 金勁宅
  5. 淸熱解鬱湯이 흰쥐의 實驗的 胃潰瘍에 미치는 影響 金商國
  6. 대한동의병리학회지 v.3 香砂六君子湯 엑기스산이 백서의 胃液分泌 및 腸管輸送能에 미치는 影響 金鍾鎬
  7. 慶凞韓醫人論文集 v.5 蒼連湯이 흰쥐의 胃潰瘍에 미치는 影響 金弘起(外)
  8. 越鞠丸과 七氣湯이 백서의 實驗的 胃潰瘍에 미치는 影響 文相元
  9. 丹參補血湯 및 保和丸이 胃潰瘍에 미치는 影響 朴東源
  10. 慶熙韓醫大 논문집 v.6 化痰, 溫胃 및 養血療法이 實驗的 胃潰瘍에 미치는 影響 尹泰汝
  11. 柴胡加龍骨牡蠣湯 엑기스가 쥐의 實驗的 胃潰瘍에 미치는 影響 李樂春
  12. 胃腸管 粘膜層의 回復에 香砂六君子湯과 烏貝散이 미치는 影響 張憲烈
  13. 萬病回春 龔廷賢
  14. 中醫內科學 上海中醫學院
  15. 臟象槪說 盛增秀;王琦
  16. 遼寧中醫雜志 v.21 no.1 碑陽虛證大白鼠模型脂質過氣化速率和抗氣化能 力的實驗的硏究 劉艶明;李德新;王曉明;易杰
  17. 景岳全書(下冊) 張景岳
  18. 中醫內科學 張伯臾
  19. 家庭醫學 의학교육연수원
  20. 大韓消火器病學會誌 v.20 no.1 소화성궤양의 內科的 治療와 合倂症에 대한 對策 송인성
  21. 大韓消火器病學會誌 v.21 no.2 십이지장궤양치료에 있어서 Misoprostol 의 효과 오광제;한광협;김동립;이상인;박인서;최홍재
  22. 大韓內科學會誌 v.24 no.2 수종의 防禦囚予 항진제가 소화성潰瘍의 治療에 미치는 影響 이종철
  23. 大韓消火器病學會誌 v.2 no.1 胃潰瘍에 대한 Ou-1308의 治療 效果 장세경
  24. 대한소화기병학회지 v.19 no.1 위궤양에 대한 Misoprostol(Cytotec)과 Cimetidine의 효과 한석원;이영석;정인식;정규원;선희식
  25. Methods of Enzymatic Analysis Aebi, H.;Bergmeyer, H. U.(eds.)
  26. Scand J. Gastroenterol, v.4 The production of acute gastric ulceration by indomethacin in the rat Djahangguiri, B.
  27. Arch. Biochem. Biophys. v.82 Tissue sulthydryl group Ellman, G. L.
  28. Am. J. Med. v.13 Endoscopic studies of gastric and duodenal injury after the use of ibuprofen, aspirin, and other nonsteroidaI antiinflammatory agents Lanza, F. L.
  29. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry, O. H.;Rosehrough, N. J.;Farr, A. L.;Randall, R. J.
  30. J. Biol. Chem. v.244 Superoxide dismutase, An enzymatic function for erythrocuprein(hemocuperin) McCord, J. M.;Fridovich, I.
  31. Anal Biochem. v.95 Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction Ohkwa, H.;Ohishi, N.;Yaki, K.
  32. Digestive Diseases and Sciences v.34 no.5 Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indomethacin in rats Okada, M.;Niida, H.;Takeuchi,K.;Okabe, S.
  33. Gut v.30 Oxygen radicals:mediators of gastrointestinal Pathophysiology Parks, D. A.
  34. Biochem. Pharmacol. v.21 Lipid perokide formation in experimental inflammation Sharma, S. C.;Mukhtar, H.;Sharma, S. K.;Krishna-Murt, C. R.
  35. Gastroenterology v.5 A Simple Method for the uniform production of gastric ulceration in the rat Shay, H.;Komarov, S. A.;Fels, S. S.;Meranze, D.;Gruenstein, M.;Siplet, H.
  36. Digestion v.49 Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats Takeuchi, K.;Ueshirma K.;Hironaka, Y.;Fujioka, Y.;Matsumoto, J.;Okabe, S.
  37. Japan J. Pharmacol. v.58 Effects of sulfhydryl-related compounds on indomethacin-induced gastric lesions in rats:RoIe of endogenous sylfhydryls in the pathogenesis Ueshima K.;Takeuchi, K.;Okabe, S.
  38. Digestive Diseases and Sciences v.33 no.2 Gastric motility is an important factor in the pathogenesis of indomethacin-induced gastric mucosal lesions in rats Ukei, S.;Takeuchi, K.;Okabe, S.